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[db-091] 3P26 : Fabricius嚢に対する性ホルモンの作用−ブルソポエチン分泌とアポトーシスを



##Begin
#Z 3P26
#A Fabricius嚢に対する性ホルモンの作用−ブルソポエチン分泌とアポトーシスを
 関連させて−
#B Effects of sex steroids on bursa of Fabricius, with special reference to
 bursopoietin synthesis and B cell apoptosis
#E1 坂部/貢
#F1 さかべ/こう
#G1 Sakabe/Kou
#J1 東海大学医学部形態学部門
#K1 とうかい だいがく いがくぶ けいたいがくぶもん
#L1 Department of Morphology, School of Medicine, Tokai University
#E2 何/威赴#F2 フェー/ウエイ
#G2 He/Wei
#J2 東海大学医学部形態学部門
#K2 とうかい だいがく いがくぶ けいたいがくぶもん
#L2 Department of Morphology, School of medicine, Tokai University
#E3 清木/勘治
#F3 せいき/かんじ
#G3 Seiki/Kanji
#J3 東海大学医学部形態学部門
#K3 とうかい だいがく けいたいがくぶもん
#L3 Department of Morphology, School of Medicine, Tokai University
#E4 赤塚/
 明
#F4 あかつか/あきら
#G4 Akatsuka/Akira
#J4 東海大学医学部形態学部門
#K4 とうかい だいがく けいたいがくぶもん
#L4 Department of Morphology, School of Medicine, Tokai University
#E5 徳永/正義
#F5 とくなが/まさよし
#G5 Tokunaga/Masayoshi
#J5 東海大学医学部形態学部門
#K5 とうかい だいがく いがくぶ けいたいがくぶもん
#L5 Department of Morphology, School of Medicine, Tokai University
#E6 中野/まゆみ
#F6 なかの/まゆみ
#G6 Nakano/Mayumi
#J6 東海大学医学部形態学部門
#K6 とうかい だいがく いがくぶ けいたいがくぶもん
#L6 Department of Morphology, School of Medicine, Tokai University
#M ファブリチウス嚢、性ホルモン、Bリンパ球、アポトーシス、ブルソポエチン、
 ブルシン
#N bursa of Fabricius, sex hormone, B cell, apoptosis, bursopoietin, bursin
#T The present study was carried out to determine the effect of sex hormone
s
 (SH) on reticular epithelial cell(REC) production/secretion of
bursopoietin(BP) by using the techniques of in situ hybridization and
quantitative HPLC. The results were as follows:(a) the RECs which staine
d
positive for BP-mRNA tended to group together, and BP-mRNA expression wa
s
observed exclusivery in their cytoplasm; (b)SH treatment caused a
progressive loss of the number of BP-mRNA-positive cell; (c) the
production of BP by RECs was significantly inhibited by SH treatment;(d)
premature B cell apoptosis was also induced by SH treatment. The above
results clearly indicate that SH directly modulate RECs to produce BP
and B cell maturation.
#Last_modified 97.04.03-09:06
#Return_path MXD01125@niftyserve.or.jp
#Sequence_number   91
##End

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