[db-102] 1P098 : ラットのプロラクチン分泌機構に及ぼす甲状腺ホルモン、

• To: db-abst@sapmed.ac.jp
• Subject: [db-102] 1P098 : ラットのプロラクチン分泌機構に及ぼす甲状腺ホルモン、
• From: hiroshiy@wakayama-med.ac.jp
• Date: Tue, 8 Apr 1997 14:45:43 +0900

##Begin
#Z 1P098
#A ラットのプロラクチン分泌機構に及ぼす甲状腺ホルモン、
エストラジオール、プロゲステロンの相互作用に関する研究
#B Effects of gonadal steroids in juvenile ovariectomized
thyroidectomized rats on PRL secretion
#E1 山内/洋
#F1 やまのうち/ひろし
#G1 Yamanouchi/Hiroshi
#J1 和歌山県立医科大学第一解剖学教室
#K1 わかやまけんりついかだいがくだいいちかいぼうがくきょうしつ
#L1 Department of Anatomy, Wakayama Medical College
#E2 椎野/昌隆
#F2 しいの/まさたか
#G2 Shiino/Masataka
#J2 和歌山県立医科大学第一解剖学教室
#K2 わかやまけんりついかだいがくだいいちかいぼうがくきょうしつ
#L2 Department of Anatomy, Wakayama Medical College
#D 昨年度、出生直後の甲状腺除去が新生ラットのプロラクチン(PRL)
分泌に及ぼす影響について報告した。今回、幼若ラットにおいて甲
状腺ホルモン、エストラジオール及びプロゲステロンがPRL合成と
放出に及ぼす相互作用を調べた。PRLmRNA合成及びPRL動態を指
標に上記のホルモンがPRL細胞に及ぼす直接的あるいは他因子を介
する間接的影響について考察を加える。
#M プロラクチン,下垂体,甲状腺ホルモン,エストラジオール,
プロゲステロン,ハロペリドール
#N prolactin, pituitary gland, thyroid hormone,
estradiol, progesterone, haloperidol
#T The effects of hypothyroidism induced by propylthiouracil(PTU)
treatment on PRL messenger ribonucleic acid(mRNA) levels
were analyzed in adenohypophyses of juvenile ovariectomized
and steroid treated female SD rats by Northern hybridization
analyses. The interaction of single injection of DA receptor
antagonist(haloperidol) on PRL gene expression was also determined.
The PTU treatment for 28 days produced a significant decrease in
PRL mRNA in all rats treated with gonadal steroids. The treatment
of estradiol for 14 days (200microg/kg BW sc./day) caused remarkable
increase of PRL secretion as well documented before. It was interesting
that progesterone (20mg/kg BW sc./day), it was known to have no direct
effect on mammotrophs, maintained the estradiol-induced high level of
PRL mRNA in pituitary in thyroidectomized rats. The results of
radioimmunoassay showed that single injection of haloperidol regulates
the release of PRL. The effect on PRL mRNA level by haloperidol was
not observed. The regulation of PRL release by haloperidol was not
influenced due to thyroid status. These results suggest that
there is an indirect mechanism of progesterone on regulation of PRL
gene expression independent from thyroid status and effect by DA.
#Last_modified 97.04.08-14:42
#Return_path hiroshiy@wakayama-med.ac.jp
#Sequence_number   102
##End

• Prev: [db-103] 3P079 : 骨内インプラントに関する基礎的研究 1.光顕とＸ線画像解析装置によ
• Next: [db-101] test : test
• Index(es):
  • Main
  • Thread