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  1. Hamada H. and Tsuruo T.  Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.  Proc. Natl. Acad. Sci. USA, 83: 7785-7789, 1986.

  2. Tsuruo T., Iida-Saito H., Kawabata H., Oh-hara T., Hamada H. and Utakoji T.  Characteristics of resistance to Adriamycin in human myelogenous leukemia K562 resistant to Adriamycin and the isolated clones.  Jpn. J. Cancer Res., 77: 682-692, 1986.

  3. Hamada H. and Tsuruo T.  Determination of membrane antigens by a covalent crosslinking method with monoclonal antibodies.  Anal. Biochem., 160: 483-488, 1987.

  4. Hamada H., Hagiwara K., Nakajima T. and Tsuruo T.  Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: Effects of verapamil, trifluoperazine, and phorbol esters.  Cancer Res., 47: 2860-2865, 1987.

  5. Yamashita N., Hamada H., Tsuruo T. and Ogata E.  Enhancement of voltage-gated Na+ channel current associated with multidrug resistance in human leukemia cells.  Cancer Res., 47: 3736-3741, 1987.

  6. FitzGerald D. J., Willingham M. C., Cardarelli C. O., Tsuruo T., Hamada H., Gottesman M. M. and Pastan I.  A monoclonal antibody-pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.  Proc. Natl. Acad. Sci. USA, 84: 4288-4292, 1987.

  7. Thiebaut F., Tsuruo T., Hamada H., Gottesman M. M., Pastan I. and Willingham M.C.  Cellular localization of the multidrug resistance gene product P-glycoprotein in normal human tissues.  Proc. Natl. Acad. Sci. USA, 84: 7735-7738, 1987.

  8. Tsuruo T., Sugimoto Y., Hamada, H. Roninson I., Okumura M., Adachi,K., Morishima Y. and Ohno R.  Detection of multidrug resis-tance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.  Jpn. J. Cancer Res., 78: 1415-1419, 1987.

  9. Willingham M. C., Richert N. D., Cornwell M. M., Tsuruo T., Hamada H., Gottesman M. M. and Pastan I.  Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.  J. Histochem. Cytochem., 35: 1451-1456, 1987.

  10. Hamada H. and Tsuruo T.  Purification of the 170- to 180 kilodalton membrane glycoprotein associated with multidrug resistance: The 170- to 180-kilodalton membrane glycoprotein is an ATPase.  J. Biol. Chem., 263: 1454-1458, 1988.

  11. Yusa K., Hamada H. and Tsuruo T.  Comparison of glutathione S-transferase activity between drug-resistant and -sensitive human tumor cells: Is glutathione S-transferase associated with multidrug resistance?  Cancer Chemother. Pharmacol., 22: 17-20, 1988.

  12. Sugawara I., Kataoka I., Morishita Y., Hamada H., Tsuruo T., Itoyama, S. and Mori S.  Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK16.  Cancer Res., 48: 1926-1929, 1988.

  13. Hamada H., Okochi E., Oh-hara T. and Tsuruo T.  Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.  Cancer Res., 48: 3173-3178, 1988.

  14. Sugawara I., Nakahama M., Hamada H., Tsuruo T. and Mori S.  Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein.  Cancer Res., 48: 4611-4614, 1988.

  15. Hamada H. and Tsuruo T.  Characterization of the ATPase activity of the 170- to 180-kilodalton membrane glycoprotein (P-glycoprotein) associated with multidrug resistance.  Cancer Res., 48: 4926-4932, 1988.

  16. Naito M., Hamada H. and Tsuruo T.  ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.  J. Biol. Chem., 263: 11887-11891, 1988.

  17. Hamada H., Okochi E., Watanabe M., Oh-hara T., Sugimoto Y., Kawabata H. and Tsuruo T.  85-kDa membrane protein specifically expressed in Adriamycin-resistant tumor cells.  Cancer Res., 48: 7082-7087, 1988.

  18. Sugawara I., Ohkochi E., Hamada H., Tsuruo T. and Mori S.  Cellular and tissue distribution of MRK20 murine monoclonal antibody-defined 85-kDa protein in Adriamycin-resistant cancer cell lines.  Jpn. J. Cancer Res., 79: 1101-1110, 1988.

  19. Sugawara I., Mizumoto K., Okochi E., Hamada, H. Tsuruo, T. and Mori S.  Immunocytochemical identification and localization of the Mr22,000 calcium-binding protein (sorcin) in an Adriamycin-resistant myelogenous leukemia cell line.  Jpn. J. Cancer Res., 80: 469-474, 1989.

  20. Ishida Y., Ohtsu T., Hamada. H., Sugimoto Y., Tobinai K., Minato K., Tsuruo T. and Shimoyama, M.  Multidrug resistance in cultured human leukemia and lymphoma cell lines detected by a monoclonal antibody, MRK16.  Jpn. J. Cancer Res., 80: 1006-1013, 1989.

  21. Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan I. and Willingham M.C.  Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170:  Evidence for localization in brain capillaries and cross-reactivity of one antibody with a muscle protein.  J. Histochem. Cytochem., 37: 159-164, 1989.

  22. Ohtsu T., Ishida Y., Tobinai K., Minato K., Hamada H., Ohkochi E., Tsuruo T. and Shimoyama M.  A novel multidrug resistance in cultured leukemia and lymphoma cells detected by a monoclonal antibody to 85-kDa protein, MRK20.  Jpn. J. Cancer Res., 80: 1133-1140, 1989.

  23. Sugawara I., Hamada H., Nakahama M., Okamoto S., Tsuruo T. and Mori S.  Further characterization of the human adrenal-derived P-glycoprotein recognized by monoclonal antibody MRK16 reacting with only human P-glycoprotein.  Jpn. J. Cancer Res., 80: 1199-1205, 1989.

  24. Kulkarni S.S., Wang Z., Spitzer G., Taha M., Hamada H., Tsuruo T., Dalton W. and Dicke K.  Elimination of drug-resistant myeloma tumor cell lines by monoclonal anti-P-glycoprotein antibody and rabbit complement.  Blood, 74: 2244-2251, 1989.

  25. Tsuruo T., Hamada H., Sato S.@and Heike Y.  Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies.  Jpn. J. Cancer Res., 80: 627-631, 1989.

  26. Sugawara I., Kodo H., Ohkochi E., Hamada H., Tsuruo,T. and Mori S.  High-level expression of MRK16 and MRK20 murine mono-clonal antibody-defined proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukemias and malignant lymphomas.  Br. J. Cancer, 60: 538-541, 1989.

  27. Hamada H., Miura K., Ariyoshi K., Heike Y., Sato S., Kameyama K., Kurosawa Y. and Tsuruo T.  Mouse-human chimeric antibody against the multidrug transporter P-glycoprotein.  Cancer Res., 50: 3167-3171, 1990.

  28. Heike Y., Hamada H., Inamura N., Sone S. and Tsuruo T.  Monoclonal anti-P-glycoprotein antibody-dependent killing of multidrug-resistant tumor cells by human mononuclear cells.  Jpn. J. Cancer Res., 81: 1155-1161, 1990.

  29. Hamada H., Maezawa K. and Tsuruo T.  Nucleotide sequences of the variable regions of a mouse monoclonal antibody MRK16.  Nucleic Acids Res., 18: 1900, 1990.

  30. Sugimoto Y., Okochi E., Hamada H., Oh-hara T. and Tsuruo T.  Detection of 300-kilodalton protein in adriamycin-resistant human tumor cells by a monoclonal antibody MRK18.  Biochem. Biophys. Res. Commun., 169: 686-691, 1990.

  31. Sugawara I., Hamada H., Tsuruo T. and Mori S.  Specialized localization of P-glycoprotein recognized by MRK16 monoclonal antibody in endothelial cells of the brain and spinal cord.  Jpn. J. Cancer Res., 81: 727-730, 1990.

  32. Moriyama M., Sugawara I., Hamada H., Tsuruo T., Kato T., Sato K., Hikage T., Watanuki T. and Mori S.  Elevated expression of P-glycoprotein in kidney and urinary bladder cancers.  Tohoku J. Exp. Med., 164: 191-201, 1991.

  33. Nishioka Y., Sone S., Heike Y., Hamada H., Ariyoshi K., Tsuruo T. and Ogura T.  Effector cell analysis of human multidrug-resistant cell killing by mouse-human chimeric antibody against P-glycoprotein.  Jpn. J. Cancer Res., 83: 644-649, 1992.

  34. Ariyoshi K., Hamada H., Naito M., Heike Y., Seimiya H., Maezawa K. and Tsuruo T.  Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein.  Jpn. J. Cancer Res., 83: 515-521, 1992.

  35. Sugimoto Y., Hamada H., Tsukahara S., Noguchi K., Yamaguchi K., Sato M. and Tsuruo T.  Molecular cloning and characterization of the complementary DNA for the Mr 85,000 protein overexpressed in Adriamycin-resistant human tumor cells.  Cancer Res., 53: 2538-2543, 1993.

  36. Dranoff G., Jaffee E., Lazenby A., Golumbek P., Levitsky H., Brose K., Jackson V., Hamada H., Pardoll D. and Mulligan R.C.  Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.  Proc. Natl. Acad. Sci. USA, 90: 3539-3543, 1993.

  37. Nakamura Y., Wakimoto H., Abe J., Kanegae Y., Saito I., Aoyagi M., Hirakawa K. and Hamada H.  Adoptive immunotherapy with murine tumor-specific T lymphocytes engineered to secrete interleukin-2.  Cancer Res., 54: 5757-5760, 1994.

  38. Abe, J. Wakimoto H., Aoyagi M., Hirakawa K. and Hamada H.  Cytokine gene-modified tumor vaccination intensified by a streptococcal preparation OK-432.  Cancer Immunol. Immunother.,  41: 82-86, 1995.

  39. Yamaguchi S., Wakimoto H., Yoshida, Y., Kanegae Y., Saito I., Aoyagi M., Hirakawa K., Amagasa T. and Hamada H.  Enhancement of retrovirus-mediated gene transduction efficiency by transient overexpression of the amphotropic receptor, GLVR2.  Nucleic Acids Res., 23: 2080-2081, 1995.

  40. Abe J., Wakimoto H., Yoshida Y., Aoyagi M., Hirakawa K. and Hamada H.  Antitumor effect induced by GM-CSF gene-modified tumor vaccination:  Comparison of adenovirus- and retrovirus-mediated genetic transduction.  J. Cancer Res. Clin. Oncol., 121: 587-592, 1995.

  41. Abe J., Wakimoto H., Tsunoda R., Okabe S., Yoshida Y., Aoyagi M., Hirakawa K. and Hamada H.  In vivo antitumor effect of cytotoxic T lymphocytes engineered to produce interferon-g by adenovirus-mediated genetic transduction.  Biochem. Biophys. Res. Commun., 218: 164-170, 1996.

  42. Abe J., Wakimoto H., Okabe S., Yoshida Y., Aoyagi M., Hirakawa K., and Hamada H.  Enhanced antitumor effect by adoptive transfer of cytotoxic T lymphocytes producing interleukin-10 by adenovirus-mediated genetic transduction.  Chi. J. Cancer Biother., 3: 96-103, 1996.

  43. Wakimoto H., Abe J., Tsunoda R., Aoyagi M., Hirakawa K. and Hamada H.  Intensified antitumor immunity by a cancer vaccine that produces granulocyte-macrophage colony-stimulating factor plus interleukin 4.  Cancer Res., 56: 1828-1833, 1996.

  44. Kanai F., Shiratori Y., Yoshida Y., Wakimoto H., Hamada H., Kanegae Y., Sait I., Nakabayashi H., Tamaoki T., Tanaka T., Lan K.-H., Kato N., Shiina S. and Omata M.  Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.  Hepatology, 23: 1359-1368, 1996.

  45. Lan K.-H., Kanai F., Shiratori Y., Okabe S., Yoshida Y., Wakimoto H., Hamada H., Tanaka T., Ohashi M, and Omata M.  Tumor-specific gene expression in carcinoembryonic antigen-producing gastric cancer cells using adnovirus vectors.  Gastroenterology, 111: 1241-1251, 1996.

  46. Tanaka T., Kanai F., Okabe S., Yoshida Y., Wakimoto H., Hamada H., Shiratori Y., Lan K.-H., Ishitobi M. and Omata M.  Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.  Cancer Res., 56: 1341-1345, 1996.

  47. Kato K., Shimozato O., Hoshi K., Wakimoto H., Hamada H., Yagita H. and Okumura K.  Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.  Proc. Natl. Acad. Sci. U.S.A., 93(17): 9085-9089, 1996.

  48. Osawa M., Hanada K., Hamada H. and Nakauchi H.  Long-term lymphohematopoietic reconstitution by a single CD34low/- hemopoietic stem cell.  Science, 273: 242-245, 1996.

  49. Hanada K., Tsunoda R. and Hamada H.  GM-CSF-induced in vivo expansion of splenic dendritic cells and their functional characterization.  J. Leukocyte Biol., 60: 181-190, 1996.

  50. Nishio N., Hisha H., Ogata H., Inaba M., Yamamoto Y., Amoh Y., Yasumizu R., Hanada K., Hamada H. and Ikehara S.  Changes in markers, receptors, and adhesion molecules expressed on murine hemopoietic stem cells after a single injection of 5-fluorouracil.  Stem Cells, 14(5): 584-591, 1996.

  51. Sato Y., Koshita Y., Hirayama M., Matuyama T., Wakimoto H., Hamada H. and Niitsu Y.  Augmented anti-tumor effects of killer cells induced by tumor necrosis factor gene-transduced autologous tumor cells from gastrointestinal cancer patients.  Human Gene Ther., 7: 1895-1905, (October 1) 1996.

  52. Lan K.-H., Kanai F., Shiratori Y., Ohashi M., Tanaka T., Okudaira T., Yoshida Y., Hamada H. and Omata.  In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.  Cancer Res., 57(19): 4279-4284, 1997.

  53. Kanai F., Lan K.-H., Shiratori Y., Tanaka T., Ohashi M., Okudaira T., Yoshida Y., Wakimoto H., Hamada H., Nakabayashi H., Tamaoki T. and Omata M.  In vivo gene therapy for a-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.  Cancer Res., 57: 461-465, 1997.

  54. Wakimoto H., Yoshida Y., Aoyagi M., Hirakawa K. and Hamada H.  Efficient retrovirus-mediated cytokine-gene transduction of primary-cultured human glioma cells for tumor vaccination therapy.  Jp. J. Cancer Res., 88: 296-305, 1997.

  55. Tanaka T., Kanai F., Lan K.-H., Ohashi M., Shiratori Y., Yoshida Y., Hamada H. and Omata M.  Adenovirus-mediated gene therapy of gastric carcinoma using cancer specific expression in vivo.  Biochem. Biophys. Res. Commum., 231(3): 775-779, 1997.

  56. Yoshida Y. and Hamada H.  Adenovirus-mediated inducible gene expression through tetracycline-controllable transactivator with nuclear localization signal.  Biochem. Biophys. Res. Commun., 230: 426-430, 1997.

  57. Yoshida Y., Emi N. and Hamada H.   VSV-G-pseudotyped retroviral packaging through adenovirus-mediated inducible gene expression.  Biochem. Biophys. Res. Commun., 232: 379-382, 1997.

  58. Yamamoto S., Wakimoto H., Aoyagi M., Hirakawa K. and Hamada H.  Modulation of motility and proliferation of glioma cells by hepatocyte growth factor.  Jp. J. Cancer Res., 88(6): 564-577, 1997.

  59. Sugawara Y., Sakata Y., Minowada S., Hamada H., Yoshida Y., Sato O., Deguchi J., Kimura H., Namba T., Makuuchi M. and Miyata T.  Adenovirus-mediated transfer of tissue-type plasminogen activator gene to human endothelial cells.  Surgery, 122(1): 91-100, 1997.

  60. Hayashi S., Nagasaka T., Koike C., Kobayashi T., Hamada H., Yokoyama I., Saito I. and Takagi H.  Effect of antisense ribozyme to alpha (1,3) galactosyl transferase gene on the expression of Gal alpha (1,3) Gal epitope.  Transplant Proc., 29(1-2A): 893, 1997.

  61. Namii Y., Hayashi S., Yokoyama I., Kobayashi T., Yasutomi M., Nagasaka T., Uchida K., Hamada H. and Takagi H.  Evidence that adenoviral vector containing the CTLA4-Ig gene improves transgene expression and graft survival.  Transplant. Proc., 29(3): 1738-1739, 1997.

  62. Sumimoto H., Tani K., Nakazaki Y., Tanabe T., Hibino H., Wu M.-S., Izawa K., Hamada H. and Asano S.  Superiority of interleukin-12-transduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice.  Cancer Gene Ther. 5: 29-37, 1997.

  63. Sumimoto H., Tani K., Nakazaki Y., Tanabe T., Hibino H., Hamada H., Azuma M. and Asano S.  GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice.  Int. J. Cancer, 73: 556-561, 1997.

  64. Hayashi S., Nagasaka T., Katayama A., Saito I., Hamada H., Kobayashi T., Yokoyama I., Ohtsuka S., Uchida K. and Takagi H.  Adenovirus-mediated gene transfer of antisense ribozyme for alpha (1,3) galactosyltransferase gene and alpha (1,2) fucosyltransferase gene in xenotransplantation.  Transplant Proc., 29(4): 2213, 1997.

  65. Hayashi S., Namii Y., Kozima T., Kobayashi T., Yokoyama,I., Saito I., Hamada H., Ohtsuka S., Uchida K. and Takagi H.  Effect of CTLA4-Ig gene transfer using adenoviral vector in organ and cell transplantation.  Transplant Proc., 29(4): 2212, 1997.

  66. Ito K., Ueda Y., Kokubune M., Urabe M., Inaba T., Mano H., Hamada H., Kitamura T., Mizoguchi H., Sakata T., Hasegawa M. and Ozawa K.  Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells.  Blood, 90(10): 3884-3892, 1997.

  67. Shibagaki N., Hanada K., Yamaguchi S., Yamashita H., Shimada S. and Hamada H.  Functional analysis of CD82 in the early phase of T cell activation:  roles in cell adhesion and signal transduction.  Eur. J. Immunol., 28(4): 1125-1133, 1998.

  68. Kanai F., Kawakami T., Hamada H., Sadata A., Yoshida Y., Tanaka T., Ohashi M., Tateishi K., Shiratori Y. and Omata M.  Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentration of 5-fluorouracil.  Cancer Res., 58: 1946-1951, 1998.

  69. Shiratori Y., Kanai F., Hikiba Y., Moriyama H., Hamada H., Matsumura M., Tanaka T., Lan K-H., Ohashi M., Okano K., Naito M. and Omata M.  Gene therapy for hepatic micrometastasis of murine colon carcinoma.  J. Hepatology 28(5): 886-895, 1998.

  70. Ohashi M., Kanai F., Tanaka T., Lan K-H., Shiratori Y., Komatsu Y., Kawabe T., Yoshida H., Hamada H. and Omata M.  In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer.  Jp. J. Cancer Res., 89: 457-462, 1998.

  71. Cao X., Ju D.W., Tao Q., Wang J., Wan T., Wang B.M., Zhang W. and Hamada H.  Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice.  Gene Therapy 5: 1130-1136, 1998.

  72. Nakazaki Y., Tani K., Lin Z-T., Sumimoto H., Hibino H., Tanabe T., Wu M-S., Izawa K., Hase H., Takahashi S., Tojo A., Azuma M., Hamada H., Mori S. and Asano S.  Vaccine effect of granulocyte-macrophage colony-stimulating factor or CD80 gene-transduced murine hematopoietic tumor cells and their co-operative enhancement of antitumor immunity.  Gene Ther., 5 (10): 1355-1362, 1998.

  73. Shinoura N., Yoshida Y., Sadata A., Hanada K., Yamamoto S., Kirino T., Asai A. and Hamada H.  Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells:  implication for gene therapy.  Human Gene Therapy, 9(14): 1983-1993, 1998.

  74. Cao X., Zhang W., He L., Xie Z., Ma S., Tao Q., Yu Y., Hamada H. and Wang J.  Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce antitumor immunity.  J. Immunol. 161(11): 6238-6244, 1998.

  75. Yoshida Y., Sadata A., Zhang W., Shinoura N. and Hamada H.  Generation of fiber-mutant recombinant adenoviruses for gene therapy of malignant glioma.  Human Gene Therapy, 9(17): 2503-2515, 1998.

  76. Shinoura N., Ohashi M., Yoshida Y., Asai A., Kirino T., Saito I. and Hamada H.  Construction, propagation, and titer estimation of recombinant adenoviruses for pro-apoptotic genes.  Human Gene Therapy, 9(18): 2683-2689, 1998.

  77. Mano Y., Ishii M., Kisara N., Kobayashi Y., Ueno Y., Kobayashi K., Hamada H. and Toyota T.  Duct formation by immortalized mouse cholangiocytes: an in vitro model for cholangiopathies.  Lab. Invest.  78(11): 1467-1468, 1998.

  78. Yasuda H., Nagata M., Arisawa K., Yoshida R., Fujihira K., Okamoto N., Moriyama H., Miki M., Saito I., Hamada H., Yokono K. and Kasuga M.  Local expression of immunoregulatory IL12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.  J. Clin. Invest. 102(10): 1807-1814, 1998.

  79. Nagasaka T., Hayashi S., Tachi Y., Liu D., Koike C., Namii Y., Katayama A., Negita M., Kobayashi T., Hamada H., Yokoyama I. and Takagi H.  Inhibitory effect of alpha(1,2) fucosyltransferase recombinant adenoviral vector on alpha Gal expression.  Transplant Proc., 30(7A): 3837-3838, 1998.

  80. Guang-Lin M., Hayashi S., Yokoyama I., Namii Y., Kobayashi T., Katayama A., Nagasaka T., Hamada H., Negita M. and Takagi H.  Adenovirus-mediated gene transfer of CTLA4IG gene results in prolonged survival of heart allograft.  Transplant Proc., 30(7):  2923-2924, 1998.

  81. Matsumoto G., Sunamura M., Shimamura H., Kodama T., Hashimoto W., Kobari M., Kato K., Takeda K., Yagita H., Okumura K., Hamada H. and Matsuno S.  Adjuvant immunotherapy using genetically engineered interleukin 12 secreting fibroblasts prevents recurrence after surgical resection of established tumors in a murine adenocarcinoma model.  Surgery, 125(3): 257-264, 1999.

  82. Ohashi M., Kanai F., Ueno H., Tanaka T., Kawakami T., Koike Y., Ikenoue T., Shiratori Y., Hamada H. and Omata M.  In vivo adenovirus-mediated p53 gene therapy for gastric carcinoma in vitro and in vivo.  Gut, 44(3): 366-371, 1999.

  83. Inaba M., Sawada H., Sadata A. and Hamada H.  In vitro circumvention of 5-fluorouracil resistance in human stomach cancer cells by adenovirus-mediated transduction of Escherichia coli uracil phophoribosyltransferase gene.  Jp. J. Cancer Res., 90 (3): 349-354, 1999.

  84. Tanaka H., Yoshizawa H., Yamaguchi Y., Ito K., Kagamu H., Suzuki E., Hamada H. and Arakawa M.  Successful adoptive immunotherapy of murine nonimmunogenic tumor with specific effector cells generated from gene-modified tumor-primed lymph node cells.   J. Immunol. 162(6): 3574-3582, 1999.

  85. Ichikawa T., Tamiya T., Adachi Y, Ono Y., Matsumoto K., Furuta T., Yoshida Y., Hamada H. and Ohmoto T.  In vivo efficacy and toxity of 5-fluorocytosine / cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus.  Cancer Gene Therapy, 7(1): 74-82, 2000.

  86. Zhang Weiping, He Long, Yuan Zhenglong, Xie Zhifang, Wang Jianli, Hamada Hirofumi, and Cao Xuetao,   Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin.  Hum. Gene Ther., 10 (7): 1151-1161, 1999.

  87. Seino K., Ogino T., Ju ST., Hamada H., Yagita H., Okumura K. and Fuqua K.  Biological factors that affect CD95 ligand-mediated inflammation.  Transplant Proc., 31(2B): 893-895, 1999.

  88. Shinoura N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax.  Oncogene, 18(41): 5703-5713, 1999.

  89. Shinoura N., Ohashi M., Yoshida Y., Kirino T., Asai A., Hashimoto M. and Hamada H.  Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas.  Cancer Gene Ther., 7(2): 224-232, 2000.

  90. Caplen NJ., Higginbotham JN., Scheel JR., Vahanian N., Yoshida Y., Hamada H., Blaese RM. and Ramsey J.  Adeno-retroviral chimeric viruses as in vivo transducing agents.  Gene Therapy 6: (3) 454-459, 1999.  

  91. Shinoura N., Yoshida Y., Tsunoda R., Ohashi M., Zhang W., Asai A., Kirino T. and Hamada H.  Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas.  Cancer Res., 59(14): 3411-3416, 1999.

  92. Matsuoka N., Yukawa H., Ishii K., Hamada H., Akimoto M., Hashimoto N. and Miyatake S.  Adenovirus-mediated gene transfer of Bcl-xl prevents cell death in primary neuronal culture of rat.    Neuroscience Lett., 270(3): 177-180, 1999.

  93. Fujii Si., Hamada H., Fujimoto K., Shimomura T. and Kawakita M.  Activated dendritic cells from bone marrow cells of mice receiving cytokine-expressing tumor cells are associated with the enhanced survival of mice bearing syngeneic tumors.  Blood., 93(12): 4328-4335, 1999.

  94. Shinoura N., Yoshida Y., Nishimura M., Muramatsu Y., Asai A., Kirino T. and Hamada H.   Expression level of Bcl-2 determines anti- or pro-apoptotic function.  Cancer Res., 59(16): 4119-4128, 1999.

  95. Deguchi J., Namba T., Hamada H., Nakaoka T., Abe J., Sato O., Miyata T., Makuuchi M., Kurokawa K. and Takuwa Y.   Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury.  Gene Ther., 6: 956-965, 1999.

  96. Takada T., Kato K., Yagita H., Hamada H. and Okumura K.  Effects of immunization with tumor cells double transfected with interleukin-2 (IL-2) and interleukin-12 (IL-12) genes on artificial metastasis of colon26 cells in BALB/c mice.  Clin Exp Metastasis, 17(2): 125-130, 1999.

  97. Hayashi S., Namii Y., Guan-Lin M., Dai-Kaku L., Kobayashi T., Nagasaka T., Yokoyama I., Hamada H. and Takagi H.  Effect of adenovirus-mediated gene transfer with CTLA4-Ig gene in organ transplantation.  Transplant Proc., 31(5): 1944-1945, 1999.

  98. Cao X., Zhang W., Wang J., Zhang M., Huang X., Hamada H. and Chen W.  Therapy of established tumour with a hybrid cellular vaccine generated by using granulocyte-macrophage colony-stimulating factor genetically modified dendritic cells.  Immunology, 97(4): 616-625, 1999.

  99. Shibagaki N., Hanada K., Yamashita H., Shimada S. and Hamada H.  Overexpression of CD82 on human T cells enhances LFA1/ICAM1-mediated cell-cell adhesion: functional association between CD82 and LFA1 in T cell activation.  Eur. J. Immunol., 29(12): 4081-4091, 1999.

  100. Shinoura N., Muramatsu Y., Nishimura M., Yoshida Y., Saito A., Yokoyama T., Furukawa T., Horii H., Hashimoto M., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of p33ING with p53 drastically augments apoptosis in gliomas.  Cancer Res., 59(21): 5521-5528, 1999.

  101. Asai A., Qiu J, Narita Y., Chi S., Saito N., Shinoura N., Hamada H., Kuchino Y. and Kirino T.  High-level calcineurin activity predisposes neuronal cells to apoptosis.  J. Biol. Chem., 274(48): 34450-34458, 1999.

  102. Kawamura K., Tasaki K., Hamada H., Takenaga K., Sakiyama S. and Tagawa M.  Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumor effect of 5-fluorouracil and induces protective immunity.  Cancer Gene Therapy, 7(4): 637-643, 2000.

  103. Sunamura M., Sun L., Lozonschi L., Duda D.G., Kodama T., Matsumoto G., Shimamura H., Kobari M., Hamada H. and Matsuno S.  The anti-angiogenesis effect of IL-12 during early growth of human pancreatic cancer in SCID mice.  Pancreas, 20(3): 227-233, 2000.

  104. Shinoura N., Yamamoto N., Yoshida Y., Fujita T., Saito N., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas.  Jpn J Cancer Res., 91(1): 41-51, 2000.

  105. Koyama F., Sawada H., Fujii H., Hirao T., Ueno M., Hamada H. and Nakano H.  The enzyme/prodrug gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene driven by the CAG promoter associated with 5-fluorocytosine administration.  J. Exp.Clin. Cancer Res. (JECCR) 19(1): 75-80, 2000.

  106. Shinoura N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas.  Cancer Gene Ther.,  7(5):732-738, 2000.

  107. Shinoura N., Saito K., Yoshida Y., Hashimoto M., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of Bax with caspase-8 controlled by myelin basic protein promoter induces enhanced apoptosis in gliomas.  Cancer Gene Ther., 7(5): 739-748, 2000.

  108. Motoi F., Sunamura M., Ding L., Duda DG., Yoshida Y., Zhang W-P., Matsuno S. and Hamada H.  Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.  Human Gene Ther., 11(2): 223-235, 2000.

  109. Shinoura N., Satou R., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of Bcl-xl protects neuronal cells from Bax-induced apoptosis.  Exp. Cell Res., 254(2): 221-231, 2000.

  110. Narita M., Takanaga K., Yoshida Y., Kadomatsu,K., Muramatsu T., Matsubara S., Hamada H., Goto S., Saisho H., Sakiyama S. and Tagawa  M.  Polyadenylation signal facilitates the expression of foreign gene that is driven by an internal promoter located in the reverse orientation to long terminal repeat of retrovirus.  Anticancer Res., 20(1A): 279-282, 2000.

  111. Qiu JH., Asai A., Chi S., Saito N., Hamada H. and Kirino T.  Protease inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons.  J. Neuroscience, 20 (1): 259-265, 2000.

  112. Kobayashi T., Okamoto K., Kobata T., Hasunuma T., Kato T., Hamada H. and Nishioka K.  Novel gene therapy for rheumatoid arthritis by FADD gene transfer: Induction of apoptosis of rheumatoid synoviocytes but not chondrocytes.  Gene Ther.,  7(6): 527-533, 2000.

  113. Kasaoka Y., Nakamoto T., Wang J., Usui T. and Hamada H.  Gene therapy for murine renal cell carcinoma using Genetically engineered tumor cells to secrete interleukin-12.  Hiroshima J. Med. Sci., 49(1): 29-35, 2000.

  114. Adachi Y., Tamiya T., Ichikawa T., Terada K., Ono Y., Matsumoto K., Furuta T., Hamada H. and Ohmoto T.  Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine.  Hum Gene Ther.,  11(1): 77-89, 2000.

  115. Kobayashi T., Okamoto K., Kobata T., Hasunuma T., Kato T., Hamada H. and Nishioka K.  Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by TNFa and bFGF is associated with the expression of apoptosis-related molecules.  Arthritis & Rheumatism, 43(5): 1106-1114, 2000.

  116. Wang J., Nakamoto T., Kasaoka Y., Usui T. and Hamada H.  Antitumor effect of murine renal cell carcinoma cells genetically modified to express B7-1 combined with cytokines secreting fibroblasts.  Hiroshima J. Med. Sci., 49(1): 73-82, 2000.

  117. Shinoura N., Muramatsu Y., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of caspase-3 with Fas ligand Induces drastic apoptosis In U373MG glioma cells. Exp. Cell Res., 256(2): 423-433., 2000.

  118. Koyama F., Sawada H., Hirao T., Fujii H., Hamada H. and Nakano H.  Combined suicide gene therapy for human colon cancer cells using  adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine.  Cancer Gene Ther., 7(7):1015-1022, 2000.

  119. Shinoura N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: Implication for gene therapy.  Hum. Gene Ther., 11(8):1123-1137, 2000.

  120. Ju DW., Tao Q., Cheng DS., Zhang W., Zhang M., Hamada H. and Cao X.  Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma.  Gene Ther., 7(4): 329-338, 2000.

  121. Kimura H., Sakata Y., Hamada H., Yoshida Y., Sato O., Deguchi J., Sugawara Y., Makuuchi M. and Miyata T.  In vivo retention of endothelial cells adenovirally transduced with tissue-type plasminogen activator and seeded onto expanded polytetrafluoroethylene.  J. Vascular Surgery, 32(2): 353-363, 2000.

  122. Kosuga M., Takahashi S., Sasaki K., Li XK., Fujino M., Hamada H., Suzuki S., Yamada M., Matsuo Y. and Okuyama T.  Adenovirus-Mediated Gene Therapy for Mucopolysaccharidosis Vll:Involvement of Cross-Correction in Wide-Spread Distribution of the Gene Products and Long-Term Effects of CTLA-4Ig.  Molecular Therap, 1(5): 406-413, 2000.

  123. Shinoura S., Yamamoto N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of caspase-8 in combination with super-repressor of NF-kB drastically induced apoptosis in gliomas.  Biochem. Biophys. Res. Commun., 271(2): 544-552, 2000.

  124. Kawamura K., Namba H., Bahar R., Miyauchi M., Maeda T., Hamada H., Sakiyama S. and Tagawa M.  Transduction of the human deoxycytidine kinase gene in rodent tumor cells induces in vivo growth retardation in syngeneic hosts.  Cancer Letters, 156(2): 151-157, 2000.

  125. Shiota G., Kunisada T., Oyama K., Udagawa A., Nomi T., Tanaka K., Tsutsumi A., Isono M., Nakamura T., Hamada H., Sakatani T., Sell S., Sato K., Ito H. and Kawasaki H.  In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats.  FEBS Lett., 470(3): 325-330, 2000.

  126. Cao X., Huang X., Ju DW., Zhang W., Hamada H. and Wang J.  Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte-macrophage colony-stimulating factor gene transfer.  Cancer Gene Ther., 7(2): 177-186, 2000.

  127. Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Transduction of Apaf-1 or caspase-9 induces apoptosis in A172 cells, which are resistant to p53-mediated apoptosis.  Biochem. Biophys. Res. Commun., 272(3): 667-673, 2000.

  128. Lei H., Ju DW., Yu Y., Tao Q., Chen G., Gu S., Hamada H. and Cao X.  Induction of potent antitumor response by vaccination with tumor lysate-pulsed macrophages engineered to secrete macrophage colony-stimulating factor and interferon-gamma.  Gene Ther., 7(8):707-713, 2000.

  129. Tani K., Nakazaki Y., Hase H., Takahashi K., Azuma M., Ohata J., Kitamura R., Komine F., Oiwa M., Masunaga A., Maekawa T., Satoh N., Adachi D., Soda Y., Machida U., Endo M., Yamazaki T., Watari K., Tojo A., Yamashita N., Tomikawa S., Eriguchi M., Hamada H., Wakumoto Y., Hanazawa K. and Okumura K.  Progress reports on immune gene therapy for stage IV renal cell cancer using lethally irradiated granulocyte-macrophage colony-stimulating factor-transduced autologous renal cancer cells.  Cancer Chemother Pharmacol, 46 Suppl: S73-76, 2000.

  130. Matsuoka N., Miyatake S., Yukawa H., Takahashi JC., Saiki M., Mori H., Ishii K., Akimoto M., Hamada H. and Hashimoto N.  Adenovirus-mediated gene transfer of basic fibroblast growth factor promotes the survival of primary-cultured rat neuronal cells.  Neuroreport, 11(9): 2001-2006, 2000.

  131. Shinoura N., Yamamoto N., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated Transfer of Fas Ligand Gene Augments Radiation-induced Apoptosis in U-373MG Glioma Cells.  Jpn. J. Cancer Res., 91(10): 1044-1050, 2000.

  132. Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Transduction of a Fiber-mutant Adenovirus for the HSVtk Gene Highly Augments the Cytopathic Effect towards Gliomas.  Jpn. J. Cancer Res., 91(10): 1028-1034, 2000.

  133. Hayashi S,. Dai-Kaku L., Namii Y., Kato T., Tokoro T., Kobayashi T., Yokoyama I., Hamada H. and Nakao A.  Effectiveness of adenovirus-mediated gene transfer with CTLA4Ig in allo and xeno-transplantation.  Transplant Proc., 32(7): 2520-2521, 2000.

  134. Hayashi S., Guang-Lin M., Yokoyama I., Namii Y., Hamada H. and Nakao A.  Adenovirus-mediated gene transfer of CTLA4Ig gene results in prolonged survival of heart allograft.  Transpl Int., 13 Suppl 1: S329-332, 2000.

  135. Seino K., Tun T., Ohshima N., Hamada H., Yoshino K., Ikeda S., Fukunaga K., Taniguchi H., Takada Y., Yuzawa K., Otsuka M., Todoroki T. and Fukao K.  Inhibition of CD95 ligand-mediated inflammation.  Transplant Proc., 32(7): 2038-2039, 2000.

  136. Shinoura N., Muramatsu Y., Asai A., Han S., Horii A., Kirino T. and Hamada H.  Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells.  Cancer Lett., 160(1): 67-73, 2000.

  137. Koyama F., Sawada H., Fujii H., Hamada H., Hirao T., Ueno M. and Nakano H.  Adenoviral-mediated transfer of escherichia coli uracil phosphoribosyltransferase (UPRT) gene to modulate the sensitivity of the human colon cancer cells to 5-fluorouracil.  Eur. J. Cancer, 36(18): 2403-2410, 2000.

  138. Kawamura K., Bahar R., Namba H., Seimiya M., Takenaga K., Hamada H., Sakiyama S. and Tagawa M.  Bystander effect in uracil phosphoribosyltransferase/5-fluorouracil-mediated suicide gene therapy is correlated with the level of intercellular communication.  Int. J. Oncology, 18(1): 117-120, 2001.

  139. Lin Hui Wang, Dian Wen Ju, Yinghao Sun, Qun Tao, Songxi Qian, Jing Mi, Hamada H., Xuetao Cao  The potent antitumor effects of combined p16 gene and GM-CSF gene therapy through efficient induction of antitumor immunity.  J. Cancer Res. Clin. Oncol., 127: 101-108, 2001.

  140. Nagayama Y., Nishihara E., Namba H., Yokoi H., Hasegawa M., Mizuguchi H., Hayakawa T., Hamada H., Yamashita S. and Niwa M.  Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated Cre/loxP system.  Cancer Gene Ther., 8(1): 36-44, 2001.

  141. Wang LH., Ju DW., Sun Y., Tao Q., Qian S., Mi J., Hamada H. and Cao X.  The potent antitumor effects of combined p16 gene and GM-CSF gene therapy through efficient induction of antitumor immunity.  J Cancer Res Clin Oncol., 127(2): 101-108, 2001.

  142. Shinohara T., Miki T., Nishimura N., Nokihara H., Hamada H., Mukaida N. and Sone S.  Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53.  Cancer Res., 61(2): 673-678, 2001.

  143. Ding L-H., Iimura E., Saijo K., Hamada H. and Ohno T.  A speedy method to detect inserted DNA fragment in cell lines transfected with retrovirus vectors.  Cytotechnology, 34: 243-252, 2000.

  144. Sugibayashi R., Shimizu T., Suzuki T., Yamamoto N., Hamada H. and Takeda K.  Upregulation of p21 (WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.  Oncogene, 20(10): 1220-1228, 2001.

  145. Shimizu T., Shimada H., Ochiai T. and Hamada H.  Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracl phosphoribosyl-transferase and herpes simplex virus thymidine kinase).  Cancer Gene Therapy, 8(7): 512-521, 2001.

  146. Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Co-transduction of apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells.  Jpn J Cancer Res., 92(4): 467-474, 2001.

  147. Kato J., Fujikawa K., Kanda M., Fukuda N., Sasaki K., Takayama T., Kobune M., Takada K., Takimoto R., Hamada H., Ikeda T. and Niitsu Y.  A Mutation, in the Iron-Responsive Element of H Ferritin mRNA, Causing Autosomal Dominant Iron Overload.  Am. J. Hum. Genet., 69: 191-197, 2001.

  148. Ohashi M., Kanai F., Tateishi K., Taniguchi H., Marignani PA., Yoshida Y., Shiratori Y., Hamada H. and Omata M.  Target gene therapy for a-fetoprotein-producing hepatocellular carcinoma by E1B55K-attenuated adenovirus.  Biochem. Biophys. Res. Commun.,  282: 529-535, 2001.

  149. Ohara N., Koyama H., Miyata T., Hamada H., Miyatake S-I., Akimoto M. and Shigematsu H.  Adenovirus-mediated ex vivo gene transfer of basic fibroblast growth factor promotes collateral development in a rabbit model of hind limb ischemia.  Gene Ther., 8: 837-845, 2001.

  150. Shinoura N., Sakurai S., Asai A., Kirino T., and Hamada H.  Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells.  Int. J. Cancer., 15:93(2): 252-261, 2001.

  151. Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells.  Neurosurgery, 49(1): 177-186; discussion 186-187, 2001.

  152. Desaknai Sz., Lumniczky K., Hidvegi E.J., Hamada H. and Safrany G.  Brain tumor treatment with IL-2 and IL-12 producing autologous cancer cell vaccines.  Adv. Exp. Med. Biol., 495: 369-372, 2001. 

  153. Nishimura S., Adachi M., Ishida T., Matsunaga T., Uchida H., Hamada H. and Imai K.  Adenovirus-mediated transfection of caspase-8 augments anoikis and inhibits peritoneal dissemination of human gastric carcinoma cells.  Cancer Res., 61(19): 7009-7014, 2001.

  154. Shinohara T., Nishimura N., Hanibuchi M., Nokihara H., Miki T., Hamada H. and Sone S.  Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice.  Int. J. Cancer, 94(1): 16-23, 2001.

  155. Nakamura H., Sekiguchi H., Akiyama S., Hamada H., Fujiwara M., Kasai Y., Ito K. and Nakao A.  Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene increases the sensitivity of esophageal cancer cells to 5-fluorouracil.  Surg. Today. , 31(9): 785-790, 2001.

  156. Fujita N., Kagamu H., Yoshizawa H., Itoh K., Kuriyama H., Matsumoto N., Ishiguro T., Tanaka J., Suzuki E., Hamada H. and Gejyo F.  CD40 Ligand Promotes Priming of Fully Potent Antitumor CD4 (+) T Cells in Draining Lymph Nodes in the Presence of Apoptotic Tumor Cells.  J. Immunol., 15;167(10): 5678-5688, 2001.

  157. Ueno M., Koyama F., Yamada Y., Fujimoto H., Takayama T., Kamada K., Naito A., Hirao S., Mukogawa T., Hamada H. and Nakajima Y.  Tumor-specific chemo-radio-gene therapy for colorectal cancer cells using adenovirus vector expressing the cytosine deaminase gene.  Anticancer Res., 21(4A): 2601-2608, 2001.

  158. Matsuoka N., Ishii K., Akimoto M., Hamada H., Hashimoto N. and Miyatake SI.  Overexpression of bFGF and Bcl-xL with adenoviral vectors protects primarily cultured-neurons against glutamate insult.  Neurosurgery, 50(4): 857-863, 2002.

  159. Shinoura N., Furitsu T., Asai A., Kirino T. and Hamada H.  Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells.  Anticancer Res., 21(5): 3261-3268, 2001.

  160. Shimada H., Liu TL., Ochiai T., Shimizu T., Haupt Y., Hamada H., Abe T., Oka M., Takiguchi M. and Hiwasa T.  Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33 (ING1) in T.Tn human esophageal carcinoma cells.  Oncogene, 21(8): 1208-1216, 2002.

  161. Uchida H., Shinoura N., Kitayama J., Watanabe T., Nagawa H. and Hamada H.  Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells.  Biochem. Biophys. Res. Commun., 292(2): 347-354, 2002.

  162. Yamamoto S., Yoshida Y., Aoyagi M., Ohno K., Hirakawa K. and Hamada H.  Reduced transduction efficiency of adenoviral vectors expressing human p53 gene by repeated transduction into glioma cells in vitro.  Clin. Cancer Res., 8(3): 913-921, 2002.

  163. Nakamura T., Sato K. and Hamada H.  Effective Gene Transfer to Human Melanomas via Integrin-Targeted Adenoviral Vectors.  Hum. Gene Ther., 13(5): 613-626, 2002.

  164. Lumniczky K., Desaknai Sz., Mangel L., Szende B., Hamada H., Hidvegi E.J. and Safrany G.  Local tumor irradiation augments the antitumor effect of cytokine-producing autologous cancer cell vaccines in a murine glioma model.  Cancer Gene Ther.,  9: 44-52, 2002.

  165. Xia DJ., Zhang WP., Zheng S., Wang J., Pan JP., Wang Q., Zhang LH., Hamada H. and Cao X.  Lymphotactin co transfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100.  Gene Ther., 9(9): 592-601, 2002.

  166. Shinoura N., Sakurai S., Shibasaki F., Asai A., Kirino T. and Hamada H.  Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas.  Br. J. Cancer, 86(4): 587-595, 2002.

  167. Kamata T., Hattori Y., Hamada H., Kizaki M., Terada M. and Ikeda Y.  Keratinocyte growth factor regulates proliferation and differentiation of hematopoietic cells expressing the receptor gene K-sam.  Exp. Hematol., 30(4): 297-305,2002.

  168. Akimoto M., Miyahara T., Arai J., Akimoto A., Hamada H., Yoshida Y. and Yoshimura N.  A new delivery system for 5-fluorouracil using prodrug and converting enzyme.  Br. J. Ophthalmol., 86(5): 581-586, 2002.

  169. Takahashi M., Sato T., Sagawa T., Lu Y., Sato Y., Iyama S., Yamada Y., Fukaura J., Takahashi S., Miyanishi K., Yamashita T., Sasaki K., Kogawa K., Hamada H., Kato J. and Niitsu Y.  E1B-55K-Deleted Adenovirus Expressing E1A-13S by AFP-Enhancer/Promoter Is Capable of Highly Specific Replication in AFP-Producing Hepatocellular Carcinoma and Eradication of Established Tumor.  Mol. Ther., 5 (5 Pt 1):  627-634, 2002.

  170. Sugibayashi R., Kiguchi Y., Shimizu T., Suzuki T., Hamada H. and Takeda K.  Up-regulation of p21 (WAF1/CIP1) levels leads to growth suppression of prostate cancer cell lines.  Anticancer Res., 22(2A): 713-719, 2002.

  171. Sakurai S., Sonoda Y., Koguchi E., Shinoura N., Hamada H. and Kasahara T.  Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G.  Biochem. Biophys. Res. Commun., 293: 174-181, 2002.

  172. Hoshida T., Sunamura M., Duda D.G., Egawa S., Miyazaki S., Shineha R., Hamada H., Ohtani H., Satomi S. and Matsuno S.  Gene Therapy for Pancreatic Cancer Using an Adenovirus Vector Encoding Soluble flt-1 Vascular Endothelial Growth Factor Receptor.  Pancreas, 25(2): 111-121, 2002.

  173. Sakurada A., Hamada H., Fukushige S., Yokoyama T., Yoshinaga K., Furukawa T., Sato S., Yajima A., Sato M., Fujimura S. and Horii A.  Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.  Int. J. Oncol., 15: 1069-1074, 1999.

  174. Nakamori M., Iwahashi M., Ueda K., Tsunoda T., Terasawa H., Hamada H. and Yamaue H.  Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with Cytosine deaminase / 5-fluorocytosine: preclinical consideration.  Jpn. J. Cancer Res., 93(6): 706-715, 2002.

  175. Satoh M., Masamune A., Sakai Y., Kikuta K., Hamada H. and Shimosegawa T.  Establishment and characterization of a simian virus 40-immortalized rat pancreatic stellate cell line.  Tohoku J. Exp. Med., 198(1): 55-69, 2002.

  176. Tanaka S., Takehashi M., Matoh N., Iida S., Suzuki T., Futaki S., Hamada H., Masliah E., Sugiura Y. and Ueda K.  Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.  J. Neurochem., 82(2): 305-315, 2002.

  177. Kambara H., Tamiya T., Ono Y., Ohtsuka S., Terada K., Adachi Y., Ichikawa T., Hamada H. and Ohmoto T.  Combined radiation and gene therapy for brain tumors with adenovirus-mediated transfer of cytosine deaminase and uracil phosphoribosyltransferase genes.  Cancer Gene Ther., 9(10): 840-845, 2002.

  178. Oonuma M., Sunamura M., Motoi F., Fukuyama S., Shimamura H., Yamauchi J., Shibuya K., Egawa S., Hamada H., Takeda K. and Matsuno S.  Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors.  Int. J. Cancer, 102(1): 51-59, 2002.

  179. Kawano Y., Kobune M., Yamaguchi M., Nakamura K., Ito Y., Sasaki K., Takahashi S., Nakamura T., Chiba H., Sato T., Matsunaga T., Azuma H., Ikebuchi K., Ikeda H., Kato J., Niitsu Y. and Hamada H.  Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subnit (hTERT)-transfected human stromal cells.  Blood, 101(2): 532-540, 2003.

  180. Uchida H., Shinoura N., Kitayama J., Watanabe T., Nagawa H. and Hamada H.  5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus- mediated transfer of caspase-8 in DLD-1 colon cancer cells.  J. Gene Med., 5(4): 287-299, 2003.

  181. Huang X., Zhang W., Wakimoto H., Hamada H. and Cao X.  Adenovirus-mediated tissue-specific cytosine deaminase gene therapy for human hepatocellular carcinoma with different AFP expression levels.  J. Exp. Ther. Oncol., 2(2): 100-106, 2002.

  182. Tsuda H., Wada T., Ito Y., Uchida H., Dehari H., Nakamura K., Sasaki K., Kobune M., Yamashita T. and Hamada H.  Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector.  Mol. Ther., 7(3): 354-365, 2003.

  183. Nakamura T., Sato K. and Hamada H.  Reduction of natural adenovirus tropism to the liver by both ablation of fiber-Coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber.  J. Virol., 77(4): 2512-2521, 2003.

  184. Ugai H., Suzuki E., Inabe K., Murata T., Hamada H. and Yokoyama KK.  Spontaneous mutations in the human gene for p53 in recombinant adenovirus during multiple passages in human embryonic kidney 293 cells.  Biochem. Biophys. Res. Commun., 300(2): 448-456, 2003.

  185. Dehari H., Ito Y., Nakamura T., Kobune M., Sasaki K., Yonekura N,Kohama G. and Hamada H.  Enhanced antitumor effect of RGD fiber-modified adenovirus for gene therapy of oral cancer.  Cancer Gene Therapy, 10(1): 75-85, 2003.

  186. Miyagi T., Koshida K., Hori O., Konaka H., Katoh H., Kitagawa Y., Mizokami A., Egawa M., Ogawa S., Hamada H. and Namiki M.  Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system.  J. Gene Med., 5(1): 30-37, 2003.

  187. Kuwahara I., Ikebuchi K., Hamada H., Niitsu Y., Miyazawa K., Ohyashiki K., Fujisawa H. and Furukawa K.  Changes in N-glycosylation of human stromal cells by telomerase expression.  Biochem. Biophys. Res. Commun., 301(2): 293-297, 2003.

  188. Koyama F., Fujii H., Mukogawa T., Ueno M., H. Hamada, Ishikawa H., Doi S., Nakao T., Matsumoto H., Shimatani H., Takeuchi T. and Nakajima Y.  Chemo-radio-gene therapy for colorectal cancer cells using the Escherichia coli uracil phosphoribosyltransferase gene.  Anticancer Res.,(23): 1343-1348, 2003.

  189. Takikawa H., Mafune K., Hamada H., Nettelbeck DM., Muller R., Makuuchi M. and Kaminishi M.  An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma.  Int. J. Oncol., 22(5): 1051-1056, 2003.

  190. Desaknai S., Lumniczky K., Esik O., Hamada H. and Safrany G.  Local tumour irradiation enhances the anti-tumour effect of a double-suicide gene therapy system in a murine glioma model.  J. Gene Med., 5(5): 377-385, 2003.

  191. Huang J., Ito Y., Kobune M., Sasaki K., Nakamura K., Dehari H., Takahashi K., Uchida H., Kato K. and Hamada H.  Myocardial injection of CA promoter-based plasmid mediates efficient transgene expression in rat heart.  J Gene Med. 5(10): 900-908. 2003.

  192. Yamauchi A., Ito Y., Morikawa M., Kobune M., Huang J., Sasaki K., Takahashi K., Nakamura K., Dehari H., Niitsu Y., Abe T. and Hamada H.  Pre-administration of angiopoietin-1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model.  J. Gene Med., 5(11): 994-1004. 2003.

  193. Ninomiya M., Koyama H., Miyata T., Hamada H., Miyatake S., Shigematsu H. and Takamoto S.  Ex vivo gene transfer of basic fibroblast growth factor improves cardiac function and blood flow in a swine chronic myocardial ischemia model.  Gene Ther., 10(14): 1152-1160, 2003.

  194. Takahashi K., Ito Y., Morikawa M., Kobune M., Huang J., Tsukamoto M., Sasaki K., Nakamura K., Dehari H., Ikeda K., Uchida H., Hirai S., Abe T. and Hamada H.  Adenoviral delivered angiopoietin-1 reduces the infarction and attenuates the progression of cardiac dysfunction in the rat model of acute myocardial infarction.  Mol. Ther., 8(4): 584-592, 2003.

  195. Kobune M., Kawano Y., Ito Y., Chiba H., Nakamura K., Tsuda H., Sasaki K., Dehari H., Uchida H., Honmou O., Takahashi S., Bizen A., Takimoto R., Matsunaga T., Kato J., Kato K., Houkin K., Niitsu Y. and Hamada H.  Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells  Exp.  Hematol. Exp. Hematol., 31(8): 715-722, 2003. published online via ScienceDirect: http://authors.elsevier.com/sd/article/S0301472X03001772

  196. Fukuda K., Abei M., Ugai H., Seo E., Wakayama M., Murata T., Todoroki T., Tanaka N., Hamada H. and Yokoyama K.  E1A, E1B Double-restricted Adenovirus for Oncolytic Gene Therapy of Gallbladder Cancer.  Cancer Res., 63(15): 4434-4440. 2003.

  197. Kobayashi T., Yamada Y., Nagashima M., Seki S., Tsutsuura M., Ito Y, Sakuma I., Hamada H., Abe T. and Tohse N.  Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes.  J. Mol. Cell Cardiol., 35(9): 1073-1082. 2003.

  198. Hagiwara S., Nakamura K., Hamada H., Sasaki K., Ito Y., Kuribayashi K., Sato T., Sato Y., Takahashi M., Kogawa K., Kato J., Terui T., Takayama T., Matsunaga T., Taira K. and Niitsu Y.  Inhibition of type I procollagen production by tRNAVal CTE-HSP47 ribozyme.  J. Gene Med., 5(9): 784-794. 2003.

  199. Huang J, Ito Y, Morikawa M, Uchida H, Kobune M, Sasaki K, Abe T, Hamada H. Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury.  Biochem Biophys Res Commun. 311(1):64-70, 2003.

  200. Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., Kato, K., Honmou, O., Houkin, H., Date, I., and Hamada, H.   BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol. Ther. 9(2):189-97, 2003.

  201. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, Bizen A, Honmou O, Niitsu Y, and Hamada, H.   Anti-tumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther., 11(14): 1155-64, 2004. 2004 May 13 [Gene Ther. , Epub ahead of print.

  202. Ishii S, Koyama H, Miyata T, Nishikage S, Hamada H, Miyatake S, Shigematsu H. Appropriate control of ex vivo gene therapy delivering basic fibroblast growth factor promotes successful and safe development of collateral vessels in rabbit model of hind limb ischemia. J. Vasc. Surg., 39(3):629-638, 2004.

  203. Ono I, Yamashita T, Hida T, Jin HY, Ito Y, Hamada H, Akasaka Y, Ishii T, Jimbow K. Combined administration of basic fibroblast growth factor protein and the hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds.  Wound Repair Regen., 12(1):67-79, 2004.

  204. Kondoh K, Koyama H, Miyata T, Takato T, Hamada H, Shigematsu H. Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor.  Cardiovasc. Res., 61(1):132-142, 2004.

  205. Kurozumi K, Tamiya T, Ono Y, Otsuka S, Kambara H, Adachi Y, Ichikawa T, Hamada H, Ohmoto T. Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus.  J. Neurooncol., 66(1-2):117-127, 2004.

  206. Okada T, Caplen NJ, Ramsey WJ, Onodera M, Shimazaki K, Nomoto T, Ajalli R, Wildner O, Morris J, Kume A, Hamada H, Blaese RM, Ozawa K. In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.  J. Gene. Med. 6(3):288-299, 2004.

  207. Yasuhara T, Shingo T, Kobayashi K, Takeuchi A, Yano A, Muraoka K, Matsui T, Miyoshi Y, Hamada H, Date I. Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease. Eur. J. Neurosci.,Mar;19(6):1494-504, 2004

  208. Kobune M, Ito Y, Kawano Y, Sasaki K, Uchida H, Nakamura K, Dehari H, Chiba H, Takimoto R, Matsunaga T, Terui T, Kato J, Niitsu Y, Hamada H.  Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-{beta}2m-/- repopulating cells.  Blood. 2004 Apr 22 [Epub ahead of print] Blood. 104(4):1002-1009, 2004.

  209. Ono I, Yamashita T, Jin HY, Ito Y, Hamada H, Akasaka Y, Nakasu M, Ogawa T, Jimbow K.  Combination of porous hydroxyapatite and cationic liposomes as a vector for BMP-2 gene therapy.  Biomaterials. 25(19):4709-18, 2004.

  210. Sako A, Kitayama J, Koyama H, Ueno H, Uchida H, Hamada H, Nagawa H.  Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer.  Cancer Res. 64(10):3624-8, 2004.

  211. Nishikage S, Koyama H, Miyata T, Ishii S, Hamada H,  Shigematsu H.  In vivo electroporation enhances plasmid-based gene transfer of basic fibroblast growth factor for the treatment of ischemic limb.  J. Surg. Res., 120(1):37-46, 2004.

  212. Ono I, Yamashita T, Hida T, Jin HY, Ito Y, Hamada H, Akasaka Y, Ishii T, Jimbow K.  Local administration of hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds.  J. Surg. Res., 120(1): 47-55, 2004.

  213. Uchida H, Tanaka T, Sasaki K, Kato K, Dehari H, Ito Y, Kobune M, Miyagishi M, Taira K, Tahara H, Hamada H.  Adenovirus-Mediated Transfer of siRNA against Survivin Induced Apoptosis and Attenuated Tumor Cell Growth in Vitro and in Vivo.  Mol. Ther., 10(1):162-71, 2004.

  214. Tani K, Azuma M, Nakazaki Y, Oyaizu N, Hase H, Ohata J, Takahashi K, OiwaMonna M, Hanazawa K, Wakumoto Y, Kawai K, Noguchi M, Soda Y, Kunisaki R, Watari K, Takahashi S, Machida U, Satoh N, Tojo A, Maekawa T, Eriguchi M, Tomikawa S, Tahara H, Inoue Y, Yoshikawa H, Yamada Y, Iwamoto A, Hamada H, Yamashita N, Okumura K, Kakizoe T, Akaza H, Fujime M, Clift S, Ando D, Mulligan R, Asano S.  Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings. Mol. Ther. 10(4):799-816, 2004.

  215. Sagawa T, Takahashi M, Sato T, Sato Y, Lu Y, Sumiyoshi T, Yamada Y, Iyama S, Fukaura J, Sasaki K, Hamada H, Miyanishi K, Takayama T, Kato J, Niitsu Y.  Prolonged survival of mice with multiple liver metastases of human colon cancer by intravenous administration of replicable E1B-55K-deleted adenovirus with E1A expressed by CEA promoter.  Mol. Ther., 10(6): 1043-1050, 2004.

  216. Chiba H, Kobune M, Kato J, Kawano Y, Ito Y, Nakamura K, Asakura S, Hamada H, Niitsu Y.  Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells.  Exp. Hematol., 232(12): 1194-1203, 2004.

  217. Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Ishii K, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O, Houkin K, Date I, Hamada H.  Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model.  Mol. Ther., 11(1): 96-104, 2005.

  218. Yasui H, Adachi M, Hamada H, Imai K.  Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand.  Int. J. Oncol., 26(2): 537-544, 2005.

  219. Huang J, Nakamura K, Ito Y, Uzuka T, Morikawa M, Hirai S, Tomihara K, Tanaka T, Masuta Y, Ishii K, Kato K, Hamada H,  Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rat.  Circulation, 112(1): 76-83, 2005.

  220. Seo E, Abei M, Wakayama M, Fukuda K, Ugai H, Murata T, Todoroki T, Matsuzaki Y, Tanaka N, Hamada H, Yokoyama KK.  Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration.  Cancer Res., 65(2): 546-252, 2005.  

  221. Yasuhara T, Shingo T, Muraoka K, Wen Ji Y, Kameda M, Takeuchi A, Yano A, Nishio S, Matsui T, Miyoshi Y, Hamada H, Date I.  The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model.  Brain Res., 1038(1): 1-10, 2005.

  222. Kobune M, Kawano Y, Kato J, Ito Y, Chiba H, Nakamura K, Fujimi A, Matsunaga T, Hamada H, Niitsu Y.  Expansion of CD34+ cells on telomerized human stromal cells without losing erythroid-differentiation potential in a serum-free condition.  Int. J. Hematol., 81(1): 18-25, 2005.

  223. Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, Sato T, Miyanishi K, Takayama T, Takahashi M, Takimoto R, Iyama S, Matsunaga T, Ohtani S, Matsuura A, Hamada H, Niitsu Y.  Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.  Blood., 106(2): 756-763 2005.

  224. Ugai H, Yamasaki T, Hirose M, Inabe K, Kujime Y, Terashima M, Liu B, Tang H, Zhao M, Murata T, Kimura M, Pan J, Obata Y, Hamada H, Yokoyama K K.  Purification of infectious adenovirus in two hours by ultracentrifugation and tangential flow filtration.  Biochem. Biophys. Res. Commun., 331(4): 1053-1060 2005.

  225. Tsuda H, Wada T, Yamashita T, Hamada H.  Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber-mutant adenoviral BMP2 gene.  J. Gene Med., 7(10): 1322-1334 2005.

  226. Ugai H, Murata T, Nagamura Y, Ugawa Y, Suzuki E, Nakata H, Kujime Y, Inamoto S, Hirose M, Inabe K, Terashima M, Yamasaki T, Liu B, Nakade K, Pan J, Kimura M, Saito I, Hamada H, Obata Y, Yokoyama KK.  A database of recombinant viruses and recombinant viral vectors available from the RIKEN DNA bank.  J. Gene Med., 7(9): 1148-1157 2005.

  227. Honma T, Honmou O, Iihoshi S, Harada K, Houkin K, Hamada H, Kocsis JD.  Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat.  Exp. Neurol., 2005 Jun 17; [Epub ahead of print]

  228. Yasuhara T, Shingo T, Muraoka K, Kameda M, Agari T, Wen Ji Y, Hayase H, Hamada H, Borlongan CV, Date I.  Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain Res., 1053(1-2): 10-8 2005.

  229. Linwong W, Hirasawa N, Aoyama S, Hamada H, Saito T, Ohuchi K.  Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.  Br. J. Pharmacol., 145(6): 818-828, 2005.

  230. Ichiba M, Shimomura T, Murai R, Hashiguchi K, Saeki T, Yoshida Y, Kanbe T, Tanabe N, Tsuchiya H, Miura N, Tajima F, Kurimasa A, Hamada H, Shiota G.  Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts.   Biochem. Biophys. Res. Commun.,335(3): 723-729, 2005.

  231. Yano A, Shingo T, Takeuchi A, Yasuhara T, Kobayashi K, Takahashi K, Muraoka K, Matsui T, Miyoshi Y, Hamada H,  Date I. Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia.   J. Neurosurg.,103(1): 104-114, 2005.

  232. Saito Y, Sunamura M, Motoi F, Abe H, Egawa S, Duda DG, Hoshida T, Fukuyama S, Hamada H, Matsuno S.  Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.  Cancer Gene Ther.,  2005 Sep 23; [Epub ahead of print] PMID: 16179928

  233. Harada N, Maniwa Y, Yoshimura M, Nagata M, Hamada H, Yokono K, Okita Y.  E1B-deleted adenovirus replicates in p53-deficient lung cancer cells due to the absence of apoptosis.  Oncol Rep., 14(5): 1155-1163, 2005.

  234. Ugai H, Inabe K, Yamasaki T, Murata T, Obata Y, Hamada H, Yokoyama KK.  Accumulation of infectious mutants in stocks during the propagation of fiber-modified recombinant adenoviruses.   Biochem. Biophys. Res. Commun.,337(3): 806-814, 2005.

  235. Nomura T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD.  I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat.  Neuroscience., 136(1): 161-169 2005.

  236. Kusaka N, Sugiu K, Tokunaga K, Katsumata A, Nishida A, Namba K, Hamada H, Nakashima H, Date I.  Enhanced brain angiogenesis in chronic cerebral hypoperfusion after administration of plasmid human vascular endothelial growth factor in combination with indirect vasoreconstructive surgery.  J. Neurosurg., 103(5): 882-890, 2005.

  237. Kobune M, Kato J, Chiba H, Kawano Y, Tanaka M, Takimoto R, Hamada H, Niitsu Y.  Telomerized human bone marrow-derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture.  Exp Hematol. 33(12): 1544-1553 2005.

  238. Saito Y, Sunamura M, Motoi F, Abe H, Egawa S, Duda DG, Hoshida T, Fukuyama S, Hamada H, Matsuno S.  Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.  Cancer Gene Ther., 13F 242-252, 2006.

  239. Nakamura T, Moriguchi R, Kogure K, Minoura A, Masuda T, Akita H, Kato K, Hamada H, Ueno M, Futaki S, and Harashima H.  Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells. Biol. Pharm. Bull. Biopharmacy, 2006.

  240. Tanaka T, Huang J, Hirai S, Kuroki M, Kuroki M, Watanabe N, Tomihara K, Kato K, and Hamada H. Carcinoembryonic antigen targeted selective genetherapy for gastric cancer through FZ33 fiber-modified adenovirus vectors. Clinical Cancer Research, 12(12): 3803-3813, 2006.

  241. Szatmari T, Lumniczky K, Desaknai S, Stephane Trajcevski S, Hidvegi J.E, Hamada H and Safrany G. Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy. Cancer Sci., 97(6): 546-553, 2006.

  242. Liu H, Honmou O, Harada K, Nakamura K, Houkin K, Hamada H, Kocsis J.D. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain., Oct; 129(Pt 10): 2734-45, 2006.

  243. Matsunaga T, Tanaka I, Kobune M, Kawano Y, Tanaka M, Kuribayashi K, Iyama S, Sato T, Sato Y, Takimoto R, Takayama T, Kato J, Ninomiya T, Hamada H, Niitsu Y. Ex vivo large scale generation of human platelets from cord blood CD34+cells. Stem Cells: 2877-2887, 2006.

  244. Horita Y, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD. Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat.  J. Neurosci. Res., 84(7): 1495-1504, 2006.

  245. Kim S, Honmou O, Kato K, Nonaka T, Houkin K, Hamada H, Kocsis JD. Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells. Brain Res., 2006.

  246. Wang H, Satoh M, Abe H, Sunamura M, Moriya T, Ishidoya S, Saito S, Hamada H, Arai Y. Oncolytic viral therapy by bladder instillation using an E1A, E1B double-restricted adenovirus in an orthotopic bladder cancer model. Urology, 68(3): 674-681, 2006

  247. Kato K, Chu P, Takahashi S, Hamada H, Kipps TJ. Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells. Exp. Hematol., 35(3): 434-442, 2007

  248. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature, 446(7134): 444-448, 2007

  249. Tomihara K, Kato K, Masuta Y, Nakamura K, Tanaka T, Hiratsuka H, Hamada H. Gene transfer of the CD40-ligand to human dendritic cells induces NK-mediated antitumor effects against human carcinoma cells. Int. J. Cancer, 120(7): 1491-1498, 2007

  250. Yamaguchi M, Azuma H, Fujihara M, Hamada H, Ikeda H. Generation of a considerable number of functional mast cells with a high basal level of FcƒΓRI expression from cord blood CD34{ cells by co-culturing them with bone marrow stromal cell line under serum-free conditions. Scandinavian journal of Immunology, 65: 581-588, 2007

  251. Ukai R, Honmou O, Harada K, Houkin K, Hamada H, Jeffery D.Kocsis. Mesenchymal stem cells derived from peripheral blood protects against ischemia. Journal of Neurotrauma, 24(3):508-520, 2007

  252. Suzuki K, Nakamura K, Kato K, Hamada H, Tsukamoto T. Exploration of target molecules for prostatecancer gene therapy. The Prostate, 67:1163-1173, 2007

  253. Onda T, Honmou O, Harada K, Houkin K, Hamada H, Jeffery D.K. Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified h MSCs after cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism:1-12, 2007