[db-008] 3A03 : マクロファージの貪食過程におけるPI3kinaseとtyrosine kinaseの関与

• To: db-abst@sapmed.ac.jp
• Subject: [db-008] 3A03 : マクロファージの貪食過程におけるPI3kinaseとtyrosine kinaseの関与
• From: araki@m.ehime-u.ac.jp
• Date: Mon, 10 Mar 1997 14:05:33 +0900 (JST)

##Begin
#Z 3A03
#A マクロファージの貪食過程におけるPI3kinaseとtyrosine kinaseの関与
#B Involvements of PI3kinase and tyrosine kinase in phagocytosis in macrophages
#E1 荒木/伸一
#F1 あらき/のぶかず
#G1 Araki/Nobukazu
#J1 愛媛大学医学部解剖学講座
#K1 えひめ だいがく いがくぶ かいぼうがくこうざ
#L1 Department of Anatomy, Ehime University School of Medicine
#E2 高島/庸一郎
#F2 たかしま/よういちろう
#G2 Takashima/Yoichiro
#J2 愛媛大学医学部解剖学講座
#K2 えひめ だいがく いがくぶ かいぼうがくこうざ
#L2 Department of Anatomy, Ehime University School of Medicine
#M PI3kinase, チロシンキナーゼ、マクロファージ、貪食作用
#N PI3kinase, tyrosine kinase, macrophages, phagocytosis
#T Involvements of PI3kinase and tyrosine kinase in phagocytosis in macrophages
Nobukazu Araki and Yoichiro Takashima (Ehime Univ. Sch. Med., Ehime)
 The effects of wortmannin and genistein on phagocytosis of IgG-opsonized sheep red blood cells (SRBC) in bone marrow-derived macrophages. One hundred nanomolar wortmannin inhibited the closure of phagosomes, but not actin filaments assembly nor phagocytic cup formation. However, actin filaments assembly and phagocytic cup formation were inhibited by 15 micromolar genistein. These results suggested that PI3kinase might be involved in closure machinery of phagosomes, and genistein might be involved in the signal transduction to actin assembly.actin filaments assembly nor phagocytic cup formation.
#Last_modified 97.03.10-14:05
#Return_path araki@m.ehime-u.ac.jp
#Sequence_number   8
##End

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