[db-014] 3A03 : マクロファージの貪食過程におけるPI3kinaseとtyrosine kinaseの関与

• To: db-abst@sapmed.ac.jp
• Subject: [db-014] 3A03 : マクロファージの貪食過程におけるPI3kinaseとtyrosine kinaseの関与
• From: araki@m.ehime-u.ac.jp
• Date: Fri, 14 Mar 1997 16:07:41 +0900 (JST)

##Begin
#Z 3A03
#A マクロファージの貪食過程におけるPI3kinaseとtyrosine kinaseの関与
#B Involvements of PI3kinase and tyrosine kinase in phagocytosis in
macrophages
#E1 荒木/伸一
#F1 あらき/のぶかず
#G1 Araki/Nobukazu
#J1 愛媛大学医学部解剖学講座
#K1 えひめ だいがく いがくぶ かいぼうがくこうざ
#L1 Department of Anatomy, Ehime University School of Medicine
#E2 高島/庸一郎
#F2 たかしま/よういちろう
#G2 Takashima/Yoichiro
#J2 愛媛大学医学部解剖学講座
#K2 えひめ だいがく いがくぶ かいぼうがくこうざ
#L2 Department of Anatomy, Ehime University School of Medicine
#M PI3kinase, チロシンキナーゼ、マクロファージ、貪食作用
#N PI3kinase, tyrosine kinase, macrophages, phagocytosis
#T Involvements of PI3kinase and tyrosine kinase in phagocytosis in
macrophages
Nobukazu Araki and Yoichiro Takashima (Ehime Univ. Sch. Med., Ehime)
 The effects of wortmannin and genistein on phagocytosis of
IgG-opsonized sheep red blood cells (SRBC) in bone marrow-derived
macrophages. One hundred nanomolar wortmannin inhibited the closure of
phagosomes, but not actin filaments assembly nor phagocytic cup formation.
However, actin filaments assembly and phagocytic cup formation were
inhibited by 15 micromolar genistein. These results suggested that
PI3kinase might be involved in closure machinery of phagosomes, and
genistein might be involved in the signal transduction to actin
assembly.actin filaments assembly nor phagocytic cup formation.
#Last_modified 97.03.14-16:08
#Return_path araki@m.ehime-u.ac.jp
#Sequence_number   14
##End

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