蛋白質タンデムリピート研究
札幌医科大学医療人育成センター
教養教育研究部門物理学 松嶋範男
研究業績
Papers (from 2004)
- Norio Matsushima and Hiroki Miyashita “Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants” Biomolecules, 2012, 2: 288-311.
- Tomoko Mikami, Hiroki Miyashita, Shintaro Takatsuka, Yoshio Kuroki, and Norio Matsushima “Molecular evolution of vertebrate Toll-like receptors: Evolutional rate difference between their leucine-rich repeats and TIR domains” Gene, 2012,503(2):235-243.
- Purevjav Enkhbayar and Norio Matsushima “HELFIT: Algorithm and applications” AIP Conf. Proc. 2012, 1479:1942-1947.
- Norio Matsushima and Purevjav Enkhbayar “Structural features of helical secondary structures and leucine-rich repeat superhelix in proteins as revealed by HELFIT analyses” AIP Conf. Proc. 2012, 1479：1948-1953.
- Purevjav Enkhbayar, Boldgiv B, and Norio Matsushima “omega-Helices” (Review), Current Topics in Peptide & Protein Research, 2011,12:17-28.
- Matsushima N,Miyashita H, Mikami T, Kuroki Y. “A nested leucine rich repeat (LRR) domain: The precursor of LRRs is a ten or eleven residue motif. BMC Microbiology (2010), 10:235-244.
- Enkhbayar P, Boldgiv B, Matsushima N. “Omega-Helices in proteins” The Protein Journal、(2010) 29(4):242-249.
- Matsushima N, Mikami T, Tanaka T, Miyashita H, Yamada K, Kuroki Y. “Analyses of Non-Leucine Rich Repeat (Non-LRR) Regions Intervening Between LRRs in Proteins” Biochim Biophys Acta. 2009, 1790(10):1217-1237 (2009)
- Nishitani C, Takahashi M, Mitsuzawa H, Shimizu T, Ariki S, Matsushima N, Kuroki Y. Mutational analysis of Cys88 of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression. Int Immunol. 21(8):925-934 (2009)
- Matsushima N, Tanaka T, Kretsinger RH. Non-globular structures of tandem repeats in Proteins. Protein & Peptide Letters, 16(11): 1297-1322 (2009)
- Matsushima N, Yoshida H, Kumaki Y, Kamiya M, Tanaka T, Izumi Y, Kretsinger RH. Flexible structures and ligand interactions of tandem repeats consisting of proline, glycine, asparagine, serine, and/or threonine rich oligopeptides in proteins. Curr Protein Pept Sci. 9(6):591-610 (2008).
- Enkhbayar P, Damdinsuren S, Osaki M, Matsushima N. HELFIT: Helix fitting by a total least squares method. Comput Biol Chem. 32(4):307-310 (2008)
- Kumaki Y, Kawano K, Hikichi K, Matsumoto T, Matsushima N. A circular loop of the 16-residue repeating unit in ice nucleation protein. Biochem Biophys Res Commun. 371(1):5-9 (2008)
- Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell. 130(5):906-917 (2007)
- Matsushima N, Hayashi N, Watanabe N, Jinbo Y, Izumi Y. Binding of trifluoperazine to apocalmodulin revealed by a combination of small-angle x-ray scattering and nuclear magnetic resonance. J. Appl. Crystallogr. 40: s179-s183 (2007)
- Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 8:124-143 (2007).
- Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H, Matsushima N, Fukase K, Kuroki Y. Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol. 177(11): 8133-8139 (2006)
- Nishitani C, Mitsuzawa H, Sano H, Shimizu T, Matsushima N, Kuroki Y. Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40. J Biol Chem. 281(50):38322-38329 (2006)
- Enkhbayar P, Hikichi K, Osaki M, Kretsinger RH, Matsushima N. 3(10)-helices in proteins are parahelices. Proteins. 64(3):691-699 (2006)
- Izumi, Y., Goto, K., Jinbo Y., Takezawa, D., Nayashi N., Matsushima, N., “Solution Structure of Plant Calmodulin in the Absence and Presence of Targets: Implications on its Structure and Function” Photon Factory Activity Report, (2006) 24 (B), 238-238.
- Izumi, Y., Nayashi N., Jinbo Y., Matsufuji T., Matsushima, N., “Tertiary Structure of Calmodulin Predicted by Bioinformatics: Experimental Verification by SAXS、2“ Photon Factory Activity Report, (2006) 24(B), 221-221.
- Izumi, Y., Nayashi N., Jinbo Y., Matsufuji T., Matsushima, N., “Tertiary Structure of Calmodulin Predicted by Bioinformatics: Experimental Verification by SAXS“ Photon Factory Activity Report, (2006) 24(B), 215-215.
- Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 62(23):2771-2791 (2005)
- Matsushima N, Enkhbayar P, Kamiya M, Osaki M, Kretsinger RH. Leucine-rich repeats (LRRs): structure, function, evolution and interaction with ligands” Drug Design Reviews 2 (4): 305-322 (2005)
- Kamiya M, Kumaki Y, Nitta K, Matsumoto T, Hikichi K, Matsushima N. The binding of copper ions to glycine-rich proteins (GRPs) from Cicer arietinum. Biochim Biophys Acta. 1722(1):69-76 (2005)
- Nishitani C, Mitsuzawa H, Hyakushima N, Sano H, Matsushima N, Kuroki Y. The Toll-like receptor 4 region Glu24-Pro34 is critical for interaction with MD-2. Biochem Biophys Res Commun. 328(2):586-590 (2005).
- Kumaki,K., Nitta,K., Hikichi,K., Matsumoto,T., Matsushima,N. :Side chain-side chain interactions of arginine with tyrosine and aspartic acid in Arg/Gly/Tyr-rich domains within plant glycine-rich RNA binding proteins. J. Biochem., (Tokyo) 136:29-37 (2004)
- Hayashi,N., Nakagawa,C., Ito,Y., Takasaki,A., Jinbo,Y., Yamakawa,Y., Titani,K., Hashimoto,K., Izumi,Y., Matsushima,N.: Myristoylation-regulated direct interaction between calcium-bound calmodulin and N-terminal region of pp60v-src. J. Mol. Biol., 338:169-180 (2004)
- Kamiya,M., Kumaki,Y., Nitta,K., Ueno,T., Watanabe,Y., Yamada,K., Matsumoto,T., Hikichi,K., Matsushima,N.:Copper binding to plant ozone-inducible proteins (OI2-2 and OI14-3). Biochim. Biophys. Res. Commun., 314:908-915(2004)
- Enkhbayar,P, Kamiya,M., Osaki,M., Matsumoto,T,, Matsushima,N. :Structural principles of Leucine-rich repeats (LRR) proteins. Proteins; Struc. Func. Bioinform., 54:394-403 (2004)
総説及び著書
- Matsushima N, Miyashita M. “Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants” Biomolecules, 2012, 2: 288-311.
- Enkhbayar P., Boldgiv B, Matsushima N. “omega-Helices”, Current Topics in Peptide & Protein Research, 2011,12:17-28.
- Matsushima N., Miyashita H., Mikami T., Yamada K. “A new method for the identification of leucine-rich rpeats by incorporating protein second struture prediction” Bioinformatics: Genome Bioinformatics and Computational Biology, (Tuteja R. editor); NOVA Sience Pulishers, pp.61-88, 2011.
- Matsushima N, Miyashita H, Mikami T, Yamada K. “Some methods to identify leucine-rich repeats in Bioinformatics: Genome Bioinformatics and Computational Biology” NOVA publishers, in preparation
- Matsushima N, Tanaka T, Kretsinger RH. Non-globular structures of tandem repeats in Proteins. Protein & Peptide Letters, 16(11): 1297-1322 (2009)
- Matsushima N, Yoshida H, Kumaki Y, Kamiya M, Tanaka T, Izumi Y, Kretsinger RH. Flexible structures and ligand interactions of tandem repeats consisting of proline, glycine, asparagine, serine, and/or threonine rich oligopeptides in proteins. Curr Protein Pept Sci. 9(6):591-610 (2008).
- Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 62(23):2771-2791 (2005)
- Matsushima N, Enkhbayar P, Kamiya M, Osaki M, Kretsinger RH. Leucine-rich repeats (LRRs): structure, function, evolution and interaction with ligands” Drug Design Reviews 2 (4): 305-322 (2005)
- プレジャブ・エンヘバヤル、松嶋範男、“メビウスの帯は自然界に存在する” 札幌医科大学保健医療学部紀要、(2005) 8:1-5.
- 松嶋範男、“骨ミネラルのＸ線小角散乱” 日本バイオレオロギー学会誌、(2004) 18 (3):32-36.
- 松嶋範男、田中剛範 “氷と蛋白質の相互作用－生物の凍結回避戦略” 札幌医科大学保健医療学部紀要 2, 1-7 (1999)
- 大柳俊夫、松嶋範男 “遺伝情報解析システムの構築とタンパク質リピート配列の研究” 札幌医科大学保健医療学部紀要 1, 1-7 (1997)
- 松嶋範男、団野源一、松田貞行、和泉義信 “タンパク質のX線溶液散乱とコンピゅ－タグラフィックス” Photon Factory News、Vol.13、No. 4, pp19-23 (1996)
- 松嶋範男 "基礎医学および分子生物学研究へのコンピュ－タ利用" 医学のあゆみ Vol. 170, No. 3, pp. 225-228, 1994.
- Izumi, Y., Wakita, M., Yoshino,H., and Matsushima, N. "Expression of function of calmodulin. in Synchrotron Radiation in Biosciences” Oxford Science Publications, Clarendon Press, (Chance, B. et al., eds.) pp. 178-186 (1994)
- 松嶋範男 ”タンパク質の反復アミノ酸配列の立体構造予測－コンピュ－タグラフィックスの利用－” 生物物理 、Vol. 31, No. 3, pp115-120, 1991
- 和泉義信、松嶋範男、能野秀典 “多機能蛋白質：カルモデュリンの酵素活性化の作用発現機構―Ｘ線溶液散乱からのアプローチ” 放射光、Vol.2, No.1, pp. 23-33, 1989
- 松嶋範男 “新しい超二次構造をもつタンパク質” 高分子、18巻、7号、p524、1990
- 松嶋範男、秋山盛雄、寺山良雄 “Ｘ線回折法による骨のリン酸カルシウム微結晶の大きさ、配向および配列分布様式の研究” 札幌医科大学人文自然科学紀要、第22巻、pp.1-10 (1981)
国際会議招待講演・口頭発表
- Norio Matsushima and Purevjav Enkhbayar, “Structural features of helical secondary structures and leucine-rich repeat superhelix in proteins as revealed by HELFIT analyses” on the “Symposium on Helix Fitting by a Total Least Squares Method” in 10th International Conference of Numerical Analysis and Applied Mathematics (ICNAAM2012), Kypriotis Hotels and Conference Center, Kos, Greece, 19-25 September 2012
- Purevjav Enkhbayar and Norio Matsushima “HELFIT: Algorithm and applications” on the “Symposium on Helix Fitting by a Total Least Squares Method” in 10th International Conference of Numerical Analysis and Applied Mathematics (ICNAAM2012), Kypriotis Hotels and Conference Center, Kos, Greece, 19-25 September 2012
- Norio Matsushima, “Molecular Evolution of Toll-like receptors” 2nd International Conference on Computation for Science and Technology (ICCST-2), 9 – 11 July, 2012, Nigde, Turky
- Norio Matsushima“A novel method to identify leucine-rich repeats (LRRs): LRRpred” 1st International Conference on Computation for Science and Technology (ICCST-I)“ August 4 – August 6, 2010, Chiang Mai, Thailand
- 熊木康博、松嶋範男“NMRによるフレキシブルなタンデムリピートの溶液構造”蛋 白質学会年会ワークショップ 「蛋白質タンデムリピートの科学」 6月16日～18日、 札幌、2010年
- Norio Matsushima* and Tomoko Mikami “Evolution, Function and Structure of Leucine-rich Repeats” Pepcon-2010 (BIT Life Sciences' 3rd Annual Protein and Peptide Conference), March 21-23 , 2010, Beijing
- Norio Matsushima “Non-globular structures protein tandem repeats” The biophysics seminar at National University of Mongolia, December 24, 2009, Ulaanbaataqr, Mongolia.
- Norio Matsushima, Takanori Tanaka, Robert H. Kretsinger “Non-globular structures protein tandem repeats (Invited lecture)” Bandung international conference on medicinal chemistry” August 6- August 8, 2009, Bandung, Indonesia
- Norio Matsushima “Flexible and/or Disordered Structures of Tandem Repeats in Proteins” BIT Life Sciences' 2nd Annual Protein and Peptide Conference (PepCon-2009). April 2 – April 4, 2009、Seoul, South Korea
- Norio Matsushima “Tandem Repeat Structures in Proteins As Revealed by New Bioinformatics Methods (Plenary lecture)” 2nd INTERNATIONAL SYMPOSIUM-CUM-RAINING COURSE ON MOLECULAR MEDICINE AND DRUG RESEARCH (MMDR-2). January 10 – January 17, 2009、Karachi, Pakistan.
- Norio matsushima “Structures and Ligand-Protein Interactions of Leucine-rich Repeats (LRRs)” Regulation in Innate Immunity from Recognition Molecules to Antimicrobial Peptide. 28-29 October 28 – 29 October, 2008、Sapporo、Japan.
- Matsushima N. “Structure and Evolution of Leucine-rich Repeats (LRRs)” International Conference on “Theoretical and Applied Biophysics” Dedicated to 25th Anniversary of the Foundation of the Biophysics Department Ulaanbaataqr, Mongolia, September 23-25, 2004.
- Enkhbayar P., Osaki M., Matsushima N. “Structural Features of 3(10)-helices in Proteins Revealed by Computer-aided Geometrical Analysis” International Conference on “Theoretical and Applied Biophysics” Dedicated to 25th Anniversary of the Foundation of the Biophysics Department” Ulaanbaataqr, Mongolia, September 23-25, 2004.
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Last updated 06.Apr.2009
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