2008年12月08日

業績目録
                                                                                                                                                              
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 　　　　　　　　　　　　　　　　　　　　　　　                                                                                                                                                                                                                                                                              

業績目録　その１　欧文原著論文　　

 

1.    Hamada H. and Tsuruo T.  Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.  Proc. Natl. Acad. Sci. USA, 83: 7785-7789, 1986.

 

2.    Tsuruo T., Iida-Saito H., Kawabata H., Oh-hara T., Hamada H. and Utakoji T.  Characteristics of resistance to Adriamycin in human myelogenous leukemia K562 resistant to Adriamycin and the isolated clones.  Jpn. J. Cancer Res., 77: 682-692, 1986.

 

3.    Hamada H. and Tsuruo T.  Determination of membrane antigens by a covalent crosslinking method with monoclonal antibodies.  Anal. Biochem., 160: 483-488, 1987.

 

4.    Hamada H., Hagiwara K., Nakajima T. and Tsuruo T.  Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: Effects of verapamil, trifluoperazine, and phorbol esters.  Cancer Res., 47: 2860-2865, 1987.

 

5.    Yamashita N., Hamada H., Tsuruo T. and Ogata E.  Enhancement of voltage-gated Na+ channel current associated with multidrug resistance in human leukemia cells.  Cancer Res., 47: 3736-3741, 1987.

 

6.    FitzGerald D. J., Willingham M. C., Cardarelli C. O., Tsuruo T., Hamada H., Gottesman M. M. and Pastan I.  A monoclonal antibody-pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.  Proc. Natl. Acad. Sci. USA, 84: 4288-4292, 1987.

 

7.    Thiebaut F., Tsuruo T., Hamada H., Gottesman M. M., Pastan I. and Willingham M.C.  Cellular localization of the multidrug resistance gene product P-glycoprotein in normal human tissues.  Proc. Natl. Acad. Sci. USA, 84: 7735-7738, 1987.

 

8.    Tsuruo T., Sugimoto Y., Hamada, H. Roninson I., Okumura M., Adachi K., Morishima Y. and Ohno R.  Detection of multidrug resis-tance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.  Jpn. J. Cancer Res., 78: 1415-1419, 1987.

 

9.    Willingham M. C., Richert N. D., Cornwell M. M., Tsuruo T., Hamada H., Gottesman M. M. and Pastan I.  Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.  J. Histochem. Cytochem., 35: 1451-1456, 1987.

 

10.    Hamada H. and Tsuruo T.  Purification of the 170- to 180 kilodalton membrane glycoprotein associated with multidrug resistance: The 170- to 180-kilodalton membrane glycoprotein is an ATPase.  J. Biol. Chem., 263: 1454-1458, 1988.

 

11.    Yusa K., Hamada H. and Tsuruo T.  Comparison of glutathione S-transferase activity between drug-resistant and -sensitive human tumor cells: Is glutathione S-transferase associated with multidrug resistance?  Cancer Chemother. Pharmacol., 22: 17-20, 1988.

 

12.    Sugawara I., Kataoka I., Morishita Y., Hamada H., Tsuruo T., Itoyama, S. and Mori S.  Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK16.  Cancer Res., 48: 1926-1929, 1988.

 

13.    Hamada H., Okochi E., Oh-hara T. and Tsuruo T.  Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.  Cancer Res., 48: 3173-3178, 1988.

 

14.    Sugawara I., Nakahama M., Hamada H., Tsuruo T. and Mori S.  Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein.  Cancer Res., 48: 4611-4614, 1988.

 

15.    Hamada H. and Tsuruo T.  Characterization of the ATPase activity of the 170- to 180-kilodalton membrane glycoprotein (P-glycoprotein) associated with multidrug resistance.  Cancer Res., 48: 4926-4932, 1988.

 

16.    Naito M., Hamada H. and Tsuruo T.  ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.  J. Biol. Chem., 263: 11887-11891, 1988.

 

17.    Hamada H., Okochi E., Watanabe M., Oh-hara T., Sugimoto Y., Kawabata H. and Tsuruo T.  85-kDa membrane protein specifically expressed in Adriamycin-resistant tumor cells.  Cancer Res., 48: 7082-7087, 1988.

 

18.    Sugawara I., Ohkochi E., Hamada H., Tsuruo T. and Mori S.  Cellular and tissue distribution of MRK20 murine monoclonal antibody-defined 85-kDa protein in Adriamycin-resistant cancer cell lines.  Jpn. J. Cancer Res., 79: 1101-1110, 1988.

 

19.    Sugawara I., Mizumoto K., Okochi E., Hamada, H. Tsuruo, T. and Mori S.  Immunocytochemical identification and localization of the Mr22,000 calcium-binding protein (sorcin) in an Adriamycin-resistant myelogenous leukemia cell line.  Jpn. J. Cancer Res., 80: 469-474, 1989.

 

20.    Ishida Y., Ohtsu T., Hamada. H., Sugimoto Y., Tobinai K., Minato K., Tsuruo T. and Shimoyama, M.  Multidrug resistance in cultured human leukemia and lymphoma cell lines detected by a monoclonal antibody, MRK16.  Jpn. J. Cancer Res., 80: 1006-1013, 1989.

 

21.    Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan I. and Willingham M.C.  Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170:  Evidence for localization in brain capillaries and cross-reactivity of one antibody with a muscle protein.  J. Histochem. Cytochem., 37: 159-164, 1989.

 

22.   　Ohtsu T., Ishida Y., Tobinai K., Minato K., Hamada H., Ohkochi E., Tsuruo T. and Shimoyama M.  A novel multidrug resistance in cultured leukemia and lymphoma cells detected by a monoclonal antibody to 85-kDa protein, MRK20.  Jpn. J. Cancer Res., 80: 1133-1140, 1989.

 

23.   　Sugawara I., Hamada H., Nakahama M., Okamoto S., Tsuruo T. and Mori S.  Further characterization of the human adrenal-derived P-glycoprotein recognized by monoclonal antibody MRK16 reacting with only human P-glycoprotein.  Jpn. J. Cancer Res., 80: 1199-1205, 1989.

 

24.   　Kulkarni S.S., Wang Z., Spitzer G., Taha M., Hamada H., Tsuruo T., Dalton W. and Dicke K.  Elimination of drug-resistant myeloma tumor cell lines by monoclonal anti-P-glycoprotein antibody and rabbit complement.  Blood, 74: 2244-2251, 1989.

 

25.    Tsuruo T., Hamada H., Sato S. and Heike Y.  Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies.  Jpn. J. Cancer Res., 80: 627-631, 1989.

 

26.     Sugawara I., Kodo H., Ohkochi E., Hamada H., Tsuruo, T. and Mori S.  High-level expression of MRK16 and MRK20 murine mono-clonal antibody-defined proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukemias and malignant lymphomas.  Br. J. Cancer, 60: 538-541, 1989.

 

27.     Hamada H., Miura K., Ariyoshi K., Heike Y., Sato S., Kameyama K., Kurosawa Y. and Tsuruo T.  Mouse-human chimeric antibody against the multidrug transporter P-glycoprotein.  Cancer Res., 50: 3167-3171, 1990.

 

28.     Heike Y., Hamada H., Inamura N., Sone S. and Tsuruo T.  Monoclonal anti-P-glycoprotein antibody-dependent killing of multidrug-resistant tumor cells by human mononuclear cells.  Jpn. J. Cancer Res., 81: 1155-1161, 1990.

 

29.     Hamada H., Maezawa K. and Tsuruo T.  Nucleotide sequences of the variable regions of a mouse monoclonal antibody MRK16.  Nucleic Acids Res., 18: 1900, 1990.

 

30.     Sugimoto Y., Okochi E., Hamada H., Oh-hara T. and Tsuruo T.  Detection of 300-kilodalton protein in adriamycin-resistant human tumor cells by a monoclonal antibody MRK18.  Biochem. Biophys. Res. Commun., 169: 686-691, 1990.

 

31.     Sugawara I., Hamada H., Tsuruo T. and Mori S.  Specialized localization of P-glycoprotein recognized by MRK16 monoclonal antibody in endothelial cells of the brain and spinal cord.  Jpn. J. Cancer Res., 81: 727-730, 1990.

 

32.     Moriyama M., Sugawara I., Hamada H., Tsuruo T., Kato T., Sato K., Hikage T., Watanuki T. and Mori S.  Elevated expression of P-glycoprotein in kidney and urinary bladder cancers.  Tohoku J. Exp. Med., 164: 191-201, 1991.

 

33.     Nishioka Y., Sone S., Heike Y., Hamada H., Ariyoshi K., Tsuruo T. and Ogura T.  Effector cell analysis of human multidrug-resistant cell killing by mouse-human chimeric antibody against P-glycoprotein.  Jpn. J. Cancer Res., 83: 644-649, 1992.

 

34.    Ariyoshi K., Hamada H., Naito M., Heike Y., Seimiya H., Maezawa K. and Tsuruo T.  Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein.  Jpn. J. Cancer Res., 83: 515-521, 1992.

 

35.    Sugimoto Y., Hamada H., Tsukahara S., Noguchi K., Yamaguchi K., Sato M. and Tsuruo T.  Molecular cloning and characterization of the complementary DNA for the Mr 85,000 protein overexpressed in Adriamycin-resistant human tumor cells.  Cancer Res., 53: 2538-2543, 1993.

 

36.    Dranoff G., Jaffee E., Lazenby A., Golumbek P., Levitsky H., Brose K., Jackson V., Hamada H., Pardoll D. and Mulligan R.C.  Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.  Proc. Natl. Acad. Sci. USA, 90: 3539-3543, 1993.

 

37.    Nakamura Y., Wakimoto H., Abe J., Kanegae Y., Saito I., Aoyagi M., Hirakawa K. and Hamada H.  Adoptive immunotherapy with murine tumor-specific T lymphocytes engineered to secrete interleukin-2.  Cancer Res., 54: 5757-5760, 1994.

 

38.    Abe, J. Wakimoto H., Aoyagi M., Hirakawa K. and Hamada H.  Cytokine gene-modified tumor vaccination intensified by a streptococcal preparation OK-432.  Cancer Immunol. Immunother., 41: 82-86, 1995.

 

39.    Yamaguchi S., Wakimoto H., Yoshida, Y., Kanegae Y., Saito I., Aoyagi M., Hirakawa K., Amagasa T. and Hamada H.  Enhancement of retrovirus-mediated gene transduction efficiency by transient overexpression of the amphotropic receptor, GLVR2.  Nucleic Acids Res., 23: 2080-2081, 1995.

 

40.    Abe J., Wakimoto H., Yoshida Y., Aoyagi M., Hirakawa K. and Hamada H.  Antitumor effect induced by GM-CSF gene-modified tumor vaccination:  Comparison of adenovirus- and retrovirus-mediated genetic transduction.  J. Cancer Res. Clin. Oncol., 121: 587-592, 1995.

 

41.    Abe J., Wakimoto H., Tsunoda R., Okabe S., Yoshida Y., Aoyagi M., Hirakawa K. and Hamada H.  In vivo antitumor effect of cytotoxic T lymphocytes engineered to produce interferon-g by adenovirus-mediated genetic transduction.  Biochem. Biophys. Res. Commun., 218: 164-170, 1996.

 

42.    Abe J., Wakimoto H., Okabe S., Yoshida Y., Aoyagi M., Hirakawa K., and Hamada H.  Enhanced antitumor effect by adoptive transfer of cytotoxic T lymphocytes producing interleukin-10 by adenovirus-mediated genetic transduction.  Chi. J. Cancer Biother., 3: 96-103, 1996.

 

43.    Wakimoto H., Abe J., Tsunoda R., Aoyagi M., Hirakawa K. and Hamada H.  Intensified antitumor immunity by a cancer vaccine that produces granulocyte-macrophage colony-stimulating factor plus interleukin 4.  Cancer Res., 56: 1828-1833, 1996.

 

44.    Kanai F., Shiratori Y., Yoshida Y., Wakimoto H., Hamada H., Kanegae Y., Sait I., Nakabayashi H., Tamaoki T., Tanaka T., Lan K.-H., Kato N., Shiina S. and Omata M.  Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.  Hepatology, 23: 1359-1368, 1996.

 

45.    Lan K.-H., Kanai F., Shiratori Y., Okabe S., Yoshida Y., Wakimoto H., Hamada H., Tanaka T., Ohashi M, and Omata M.  Tumor-specific gene expression in carcinoembryonic antigen-producing gastric cancer cells using adnovirus vectors.  Gastroenterology, 111: 1241-1251, 1996.

 

46.    Tanaka T., Kanai F., Okabe S., Yoshida Y., Wakimoto H., Hamada H., Shiratori Y., Lan K.-H., Ishitobi M. and Omata M.  Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.  Cancer Res., 56: 1341-1345, 1996.

 

47.    Kato K., Shimozato O., Hoshi K., Wakimoto H., Hamada H., Yagita H. and Okumura K.  Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.  Proc. Natl. Acad. Sci. U.S.A., 93(17): 9085-9089, 1996

 

48.    Osawa M., Hanada K., Hamada H. and Nakauchi H.  Long-term lymphohematopoietic reconstitution by a single CD34low/- hemopoietic stem cell.  Science, 273: 242-245, 1996.

 

49.    Hanada K., Tsunoda R. and Hamada H.  GM-CSF-induced in vivo expansion of splenic dendritic cells and their functional characterization.  J. Leukocyte Biol., 60: 181-190, 1996.

 

50.    Nishio N., Hisha H., Ogata H., Inaba M., Yamamoto Y., Amoh Y., Yasumizu R., Hanada K., Hamada H. and Ikehara S.  Changes in markers, receptors, and adhesion molecules expressed on murine hemopoietic stem cells after a single injection of 5-fluorouracil.  Stem Cells, 14(5): 584-591, 1996.

 

51.    Sato Y., Koshita Y., Hirayama M., Matuyama T., Wakimoto H., Hamada H. and Niitsu Y.  Augmented anti-tumor effects of killer cells induced by tumor necrosis factor gene-transduced autologous tumor cells from gastrointestinal cancer patients.  Human Gene Ther., 7: 1895-1905, (October 1) 1996.

 

52.    Lan K.-H., Kanai F., Shiratori Y., Ohashi M., Tanaka T., Okudaira T., Yoshida Y., Hamada H. and Omata.  In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.  Cancer Res., 57(19): 4279-4284, 1997.

 

53.    Kanai F., Lan K.-H., Shiratori Y., Tanaka T., Ohashi M., Okudaira T., Yoshida Y., Wakimoto H., Hamada H., Nakabayashi H., Tamaoki T. and Omata M.  In vivo gene therapy for a-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.  Cancer Res., 57: 461-465, 1997.

 

54.    Wakimoto H., Yoshida Y., Aoyagi M., Hirakawa K. and Hamada H.  Efficient retrovirus-mediated cytokine-gene transduction of primary-cultured human glioma cells for tumor vaccination therapy.  Jp. J. Cancer Res., 88: 296-305, 1997.

 

55.    Tanaka T., Kanai F., Lan K.-H., Ohashi M., Shiratori Y., Yoshida Y., Hamada H. and Omata M.  Adenovirus-mediated gene therapy of gastric carcinoma using cancer specific expression in vivo.  Biochem. Biophys. Res. Commum., 231(3): 775-779, 1997.

 

56.    Yoshida Y. and Hamada H.  Adenovirus-mediated inducible gene expression through tetracycline-controllable transactivator with nuclear localization signal.  Biochem. Biophys. Res. Commun., 230: 426-430, 1997.

 

57.    Yoshida Y., Emi N. and Hamada H.  VSV-G-pseudotyped retroviral packaging through adenovirus-mediated inducible gene expression.  Biochem. Biophys. Res. Commun., 232: 379-382, 1997.

 

58.    Yamamoto S., Wakimoto H., Aoyagi M., Hirakawa K. and Hamada H.  Modulation of motility and proliferation of glioma cells by hepatocyte growth factor.  Jp. J. Cancer Res., 88(6): 564-577, 1997.

 

59.    Sugawara Y., Sakata Y., Minowada S., Hamada H., Yoshida Y., Sato O., Deguchi J., Kimura H., Namba T., Makuuchi M. and Miyata T.  Adenovirus-mediated transfer of tissue-type plasminogen activator gene to human endothelial cells.  Surgery, 122(1): 91-100, 1997.

 

60.    Hayashi S., Nagasaka T., Koike C., Kobayashi T., Hamada H., Yokoyama I., Saito I. and Takagi H.  Effect of antisense ribozyme to alpha (1,3) galactosyl transferase gene on the expression of Gal alpha (1,3) Gal epitope.  Transplant Proc., 29(1-2A): 893, 1997.

 

61.    Namii Y., Hayashi S., Yokoyama I., Kobayashi T., Yasutomi M., Nagasaka T., Uchida K., Hamada H. and Takagi H.  Evidence that adenoviral vector containing the CTLA4-Ig gene improves transgene expression and graft survival.  Transplant. Proc., 29(3): 1738-1739, 1997.

 

62.    Sumimoto H., Tani K., Nakazaki Y., Tanabe T., Hibino H., Wu M.-S., Izawa K., Hamada H. and Asano S.  Superiority of interleukin-12-transduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice.  Cancer Gene Ther. 5: 29-37, 1997.

 

63.    Sumimoto H., Tani K., Nakazaki Y., Tanabe T., Hibino H., Hamada H., Azuma M. and Asano S.  GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice.  Int. J. Cancer, 73: 556-561, 1997.

 

64.    Hayashi S., Nagasaka T., Katayama A., Saito I., Hamada H., Kobayashi T., Yokoyama I., Ohtsuka S., Uchida K. and Takagi H.  Adenovirus-mediated gene transfer of antisense ribozyme for alpha (1,3) galactosyltransferase gene and alpha (1,2) fucosyltransferase gene in xenotransplantation.  Transplant Proc., 29(4): 2213, 1997.

 

65.    Hayashi S., Namii Y., Kozima T., Kobayashi T., Yokoyama,I., Saito I., Hamada H., Ohtsuka S., Uchida K. and Takagi H.  Effect of CTLA4-Ig gene transfer using adenoviral vector in organ and cell transplantation.  Transplant Proc., 29(4): 2212, 1997.

 

66.    Ito K., Ueda Y., Kokubune M., Urabe M., Inaba T., Mano H., Hamada H., Kitamura T., Mizoguchi H., Sakata T., Hasegawa M. and Ozawa K.  Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells.  Blood, 90(10): 3884-3892, 1997.

 

67.    Shibagaki N., Hanada K., Yamaguchi S., Yamashita H., Shimada S. and Hamada H.  Functional analysis of CD82 in the early phase of T cell activation:  roles in cell adhesion and signal transduction.  Eur. J. Immunol., 28(4): 1125-1133, 1998.

 

68.    Kanai F., Kawakami T., Hamada H., Sadata A., Yoshida Y., Tanaka T., Ohashi M., Tateishi K., Shiratori Y. and Omata M.  Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentration of 5-fluorouracil.  Cancer Res., 58: 1946-1951, 1998.

 

69.    Shiratori Y., Kanai F., Hikiba Y., Moriyama H., Hamada H., Matsumura M., Tanaka T., Lan K-H., Ohashi M., Okano K., Naito M. and Omata M.  Gene therapy for hepatic micrometastasis of murine colon carcinoma.  J. Hepatology 28(5): 886-895, 1998.

 

70.    Ohashi M., Kanai F., Tanaka T., Lan K-H., Shiratori Y., Komatsu Y., Kawabe T., Yoshida H., Hamada H. and Omata M.  In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer.  Jp. J. Cancer Res., 89: 457-462, 1998.

 

71.    Cao X., Ju D.W., Tao Q., Wang J., Wan T., Wang B.M., Zhang W. and Hamada H.  Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice.  Gene Therapy 5: 1130-1136, 1998.

 

72.    Nakazaki Y., Tani K., Lin Z-T., Sumimoto H., Hibino H., Tanabe T., Wu M-S., Izawa K., Hase H., Takahashi S., Tojo A., Azuma M., Hamada H., Mori S. and Asano S.  Vaccine effect of granulocyte-macrophage colony-stimulating factor or CD80 gene-transduced murine hematopoietic tumor cells and their co-operative enhancement of antitumor immunity.  Gene Ther., 5 (10): 1355-1362, 1998.

 

73.    Shinoura N., Yoshida Y., Sadata A., Hanada K., Yamamoto S., Kirino T., Asai A. and Hamada H.  Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells:  implication for gene therapy.  Human Gene Therapy, 9(14): 1983-1993, 1998.

 

74.    Cao X., Zhang W., He L., Xie Z., Ma S., Tao Q., Yu Y., Hamada H. and Wang J.  Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce antitumor immunity.  J. Immunol. 161(11): 6238-6244, 1998.

 

75.    Yoshida Y., Sadata A., Zhang W., Shinoura N. and Hamada H.  Generation of fiber-mutant recombinant adenoviruses for gene therapy of malignant glioma.  Human Gene Therapy, 9(17): 2503-2515, 1998.

 

76.    Shinoura N., Ohashi M., Yoshida Y., Asai A., Kirino T., Saito I. and Hamada H.  Construction, propagation, and titer estimation of recombinant adenoviruses for pro-apoptotic genes.  Human Gene Therapy, 9(18): 2683-2689, 1998.

 

77.    Mano Y., Ishii M., Kisara N., Kobayashi Y., Ueno Y., Kobayashi K., Hamada H. and Toyota T.  Duct formation by immortalized mouse cholangiocytes: an in vitro model for cholangiopathies.  Lab. Invest., 78(11): 1467-1468, 1998.

 

78.    Yasuda H., Nagata M., Arisawa K., Yoshida R., Fujihira K., Okamoto N., Moriyama H., Miki M., Saito I., Hamada H., Yokono K. and Kasuga M.  Local expression of immunoregulatory IL12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.  J. Clin. Invest., 102(10): 1807-1814, 1998.

 

79.    Nagasaka T., Hayashi S., Tachi Y., Liu D., Koike C., Namii Y., Katayama A., Negita M., Kobayashi T., Hamada H., Yokoyama I. and Takagi H.  Inhibitory effect of alpha (1,2) fucosyltransferase recombinant adenoviral vector on alpha Gal expression.  Transplant Proc., 30(7A): 3837-3838, 1998.

 

80.    Guang-Lin M., Hayashi S., Yokoyama I., Namii Y., Kobayashi T., Katayama A., Nagasaka T., Hamada H., Negita M. and Takagi H.  Adenovirus-mediated gene transfer of CTLA4IG gene results in prolonged survival of heart allograft.  Transplant Proc., 30(7):  2923-2924, 1998.

 

81.    Matsumoto G., Sunamura M., Shimamura H., Kodama T., Hashimoto W., Kobari M., Kato K., Takeda K., Yagita H., Okumura K., Hamada H. and Matsuno S.  Adjuvant immunotherapy using genetically engineered interleukin 12 secreting fibroblasts prevents recurrence after surgical resection of established tumors in a murine adenocarcinoma model.  Surgery, 125(3): 257-264, 1999.

 

82.    Ohashi M., Kanai F., Ueno H., Tanaka T., Kawakami T., Koike Y., Ikenoue T., Shiratori Y., Hamada H. and Omata M.  In vivo adenovirus-mediated p53 gene therapy for gastric carcinoma in vitro and in vivo.  Gut, 44(3): 366-371, 1999.

 

83.    Inaba M., Sawada H., Sadata A. and Hamada H.  In vitro circumvention of 5-fluorouracil resistance in human stomach cancer cells by adenovirus-mediated transduction of Escherichia coli uracil phophoribosyltransferase gene.  Jp. J. Cancer Res., 90 (3): 349-354, 1999.

 

84.    Tanaka H., Yoshizawa H., Yamaguchi Y., Ito K., Kagamu H., Suzuki E., Hamada H. and Arakawa M.  Successful adoptive immunotherapy of murine nonimmunogenic tumor with specific effector cells generated from gene-modified tumor-primed lymph node cells.   J. Immunol. 162(6): 3574-3582, 1999.

 

85.    Ichikawa T., Tamiya T., Adachi Y, Ono Y., Matsumoto K., Furuta T., Yoshida Y., Hamada H. and Ohmoto T.  In vivo efficacy and toxity of 5-fluorocytosine / cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus.  Cancer Gene Therapy, 7(1): 74-82, 2000.

 

86.       Zhang Weiping, He Long, Yuan Zhenglong, Xie Zhifang, Wang Jianli, Hamada Hirofumi, and Cao Xuetao.  Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin.  Hum. Gene Ther., 10 (7): 1151-1161, 1999.

 

87.    Seino K., Ogino T., Ju ST., Hamada H., Yagita H., Okumura K. and Fuqua K.  Biological factors that affect CD95 ligand-mediated inflammation.  Transplant Proc., 31(2B): 893-895, 1999.

 

88.    Shinoura N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax.  Oncogene, 18(41): 5703-5713, 1999.

 

89.    Shinoura N., Ohashi M., Yoshida Y., Kirino T., Asai A., Hashimoto M. and Hamada H.  Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas.  Cancer Gene Ther., 7(2): 224-232, 2000.

 

90.    Caplen NJ., Higginbotham JN., Scheel JR., Vahanian N., Yoshida Y., Hamada H., Blaese RM. and Ramsey J.  Adeno-retroviral chimeric viruses as in vivo transducing agents.  Gene Therapy 6: (3) 454-459, 1999.

 

91.    Shinoura N., Yoshida Y., Tsunoda R., Ohashi M., Zhang W., Asai A., Kirino T. and Hamada H.  Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas.  Cancer Res., 59(14): 3411-3416, 1999.

 

92.    Matsuoka N., Yukawa H., Ishii K., Hamada H., Akimoto M., Hashimoto N. and Miyatake S.  Adenovirus-mediated gene transfer of Bcl-xl prevents cell death in primary neuronal culture of rat.  Neuroscience Lett., 270(3): 177-180, 1999.

 

93.    Fujii Si., Hamada H., Fujimoto K., Shimomura T. and Kawakita M.  Activated dendritic cells from bone marrow cells of mice receiving cytokine-expressing tumor cells are associated with the enhanced survival of mice bearing syngeneic tumors.  Blood., 93(12): 4328-4335, 1999.

 

94.   Shinoura N., Yoshida Y., Nishimura M., Muramatsu Y., Asai A., Kirino T. and Hamada H.  Expression level of Bcl-2 determines anti- or pro-apoptotic function.  Cancer Res., 59(16): 4119-4128, 1999.

 

95.    Deguchi J., Namba T., Hamada H., Nakaoka T., Abe J., Sato O., Miyata T., Makuuchi M., Kurokawa K. and Takuwa Y.  Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury.  Gene Ther., 6: 956-965, 1999.

 

96.   Takada T., Kato K., Yagita H., Hamada H. and Okumura K.  Effects of immunization with tumor cells double transfected with interleukin-2 (IL-2) and interleukin-12 (IL-12) genes on artificial metastasis of colon26 cells in BALB/c mice.  Clin Exp Metastasis, 17(2): 125-130, 1999.

 

97.   Hayashi S., Namii Y., Guan-Lin M., Dai-Kaku L., Kobayashi T., Nagasaka T., Yokoyama I., Hamada H. and Takagi H.  Effect of adenovirus-mediated gene transfer with CTLA4-Ig gene in organ transplantation.  Transplant Proc., 31(5): 1944-1945, 1999.

 

98.   Cao X., Zhang W., Wang J., Zhang M., Huang X., Hamada H. and Chen W.  Therapy of established tumour with a hybrid cellular vaccine generated by using granulocyte-macrophage colony-stimulating factor genetically modified dendritic cells.  Immunology, 97(4): 616-625, 1999.

 

99.    Shibagaki N., Hanada K., Yamashita H., Shimada S. and Hamada H.  Overexpression of CD82 on human T cells enhances LFA1/ICAM1-mediated cell-cell adhesion: functional association between CD82 and LFA1 in T cell activation.  Eur. J. Immunol., 29(12): 4081-4091, 1999.

 

100. Shinoura N., Muramatsu Y., Nishimura M., Yoshida Y., Saito A., Yokoyama T., Furukawa T., Horii H., Hashimoto M., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of p33ING with p53 drastically augments apoptosis in gliomas.  Cancer Res., 59(21): 5521-5528, 1999.

 

101.   Asai A., Qiu J, Narita Y., Chi S., Saito N., Shinoura N., Hamada H., Kuchino Y. and Kirino T.  High-level calcineurin activity predisposes neuronal cells to apoptosis.  J. Biol. Chem., 274(48): 34450-34458, 1999.

 

102.   Kawamura K., Tasaki K., Hamada H., Takenaga K., Sakiyama S. and Tagawa M.  Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumor effect of 5-fluorouracil and induces protective immunity.  Cancer Gene Therapy, 7(4): 637-643, 2000.

 

103.   Sunamura M., Sun L., Lozonschi L., Duda D.G., Kodama T., Matsumoto G., Shimamura H., Kobari M., Hamada H. and Matsuno S.  The anti-angiogenesis effect of IL-12 during early growth of human pancreatic cancer in SCID mice.  Pancreas, 20(3): 227-233, 2000.

 

104.   Shinoura N., Yamamoto N., Yoshida Y., Fujita T., Saito N., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas.  Jpn J Cancer Res., 91(1): 41-51, 2000.

 

105.   Koyama F., Sawada H., Fujii H., Hirao T., Ueno M., Hamada H. and Nakano H.  The enzyme/prodrug gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene driven by the CAG promoter associated with 5-fluorocytosine administration.  J. Exp.Clin. Cancer Res. (JECCR), 19(1): 75-80, 2000.

 

106.   Shinoura N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas.  Cancer Gene Ther., 7(5): 732-738, 2000.

 

107.   Shinoura N., Saito K., Yoshida Y., Hashimoto M., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of Bax with caspase-8 controlled by myelin basic protein promoter induces enhanced apoptosis in gliomas.  Cancer Gene Ther., 7(5): 739-748, 2000.

 

108.   Motoi F., Sunamura M., Ding L., Duda DG., Yoshida Y., Zhang W-P., Matsuno S. and Hamada H.  Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.  Human Gene Ther., 11(2): 223-235, 2000.

 

109.   Shinoura N., Satou R., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of Bcl-xl protects neuronal cells from Bax-induced apoptosis.  Exp. Cell Res., 254(2): 221-231, 2000.

 

110.   Narita M., Takanaga K., Yoshida Y., Kadomatsu K., Muramatsu T., Matsubara S., Hamada H., Goto S., Saisho H., Sakiyama S. and Tagawa  M.  Polyadenylation signal facilitates the expression of foreign gene that is driven by an internal promoter located in the reverse orientation to long terminal repeat of retrovirus.  Anticancer Res., 20(1A): 279-282, 2000.

 

111.   Qiu JH., Asai A., Chi S., Saito N., Hamada H. and Kirino T.  Protease inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons.  J. Neuroscience, 20 (1): 259-265, 2000.

 

112.   Kobayashi T., Okamoto K., Kobata T., Hasunuma T., Kato T., Hamada H. and Nishioka K.  Novel gene therapy for rheumatoid arthritis by FADD gene transfer: Induction of apoptosis of rheumatoid synoviocytes but not chondrocytes.  Gene Ther.,  7(6): 527-533, 2000.

 

113.   Kasaoka Y., Nakamoto T., Wang J., Usui T. and Hamada H.  Gene therapy for murine renal cell carcinoma using Genetically engineered tumor cells to secrete interleukin-12.  Hiroshima J. Med. Sci., 49(1): 29-35, 2000.

 

114.   Adachi Y., Tamiya T., Ichikawa T., Terada K., Ono Y., Matsumoto K., Furuta T., Hamada H. and Ohmoto T.  Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine.  Hum Gene Ther.,  11(1): 77-89, 2000.

 

115.   Kobayashi T., Okamoto K., Kobata T., Hasunuma T., Kato T., Hamada H. and Nishioka K.  Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by TNFa and bFGF is associated with the expression of apoptosis-related molecules.  Arthritis & Rheumatism, 43(5): 1106-1114, 2000.

 

116.   Wang J., Nakamoto T., Kasaoka Y., Usui T. and Hamada H.  Antitumor effect of murine renal cell carcinoma cells genetically modified to express B7-1 combined with cytokines secreting fibroblasts.  Hiroshima J. Med. Sci., 49(1): 73-82, 2000.

 

117.   Shinoura N., Muramatsu Y., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of caspase-3 with Fas ligand Induces drastic apoptosis In U373MG glioma cells. Exp. Cell Res., 256(2): 423-433., 2000.

 

118.   Koyama F., Sawada H., Hirao T., Fujii H., Hamada H. and Nakano H.  Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine.  Cancer Gene Ther., 7(7):1015-1022, 2000.

 

119.   Shinoura N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: Implication for gene therapy.  Hum. Gene Ther., 11(8):1123-1137, 2000.

 

120.   Ju DW., Tao Q., Cheng DS., Zhang W., Zhang M., Hamada H. and Cao X.  Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma.  Gene Ther., 7(4): 329-338, 2000.

 

121.   Kimura H., Sakata Y., Hamada H., Yoshida Y., Sato O., Deguchi J., Sugawara Y., Makuuchi M. and Miyata T.  In vivo retention of endothelial cells adenovirally transduced with tissue-type plasminogen activator and seeded onto expanded polytetrafluoroethylene.  J. Vascular Surgery, 32(2): 353-363, 2000.

 

122.   Kosuga M., Takahashi S., Sasaki K., Li XK., Fujino M., Hamada H., Suzuki S., Yamada M., Matsuo Y. and Okuyama T.  Adenovirus-Mediated Gene Therapy for Mucopolysaccharidosis Vll:Involvement of Cross-Correction in Wide-Spread Distribution of the Gene Products and Long-Term Effects of CTLA-4Ig.  Molecular Therap, 1(5): 406-413, 2000.

 

123.   Shinoura S., Yamamoto N., Yoshida Y., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated transfer of caspase-8 in combination with super-repressor of NF-kB drastically induced apoptosis in gliomas.  Biochem. Biophys. Res. Commun., 271(2): 544-552, 2000.

 

124.   Kawamura K., Namba H., Bahar R., Miyauchi M., Maeda T., Hamada H., Sakiyama S. and Tagawa M.  Transduction of the human deoxycytidine kinase gene in rodent tumor cells induces in vivo growth retardation in syngeneic hosts.  Cancer Letters, 156(2): 151-157, 2000.

 

125.   Shiota G., Kunisada T., Oyama K., Udagawa A., Nomi T., Tanaka K., Tsutsumi A., Isono M., Nakamura T., Hamada H., Sakatani T., Sell S., Sato K., Ito H. and Kawasaki H.  In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats.  FEBS Lett., 470(3): 325-330, 2000.

 

126.   Cao X., Huang X., Ju DW., Zhang W., Hamada H. and Wang J.  Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte-macrophage colony-stimulating factor gene transfer.  Cancer Gene Ther., 7(2): 177-186, 2000.

 

127.   Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Transduction of Apaf-1 or caspase-9 induces apoptosis in A172 cells, which are resistant to p53-mediated apoptosis.  Biochem. Biophys. Res. Commun., 272(3): 667-673, 2000.

 

128.   Lei H., Ju DW., Yu Y., Tao Q., Chen G., Gu S., Hamada H. and Cao X.  Induction of potent antitumor response by vaccination with tumor lysate-pulsed macrophages engineered to secrete macrophage colony-stimulating factor and interferon-gamma.  Gene Ther., 7(8):707-713, 2000.

 

129.   Tani K., Nakazaki Y., Hase H., Takahashi K., Azuma M., Ohata J., Kitamura R., Komine F., Oiwa M., Masunaga A., Maekawa T., Satoh N., Adachi D., Soda Y., Machida U., Endo M., Yamazaki T., Watari K., Tojo A., Yamashita N., Tomikawa S., Eriguchi M., Hamada H., Wakumoto Y., Hanazawa K. and Okumura K.  Progress reports on immune gene therapy for stage IV renal cell cancer using lethally irradiated granulocyte-macrophage colony-stimulating factor-transduced autologous renal cancer cells.  Cancer Chemother Pharmacol, 46 Suppl: S73-76, 2000.

 

130.   Matsuoka N., Miyatake S., Yukawa H., Takahashi JC., Saiki M., Mori H., Ishii K., Akimoto M., Hamada H. and Hashimoto N.  Adenovirus-mediated gene transfer of basic fibroblast growth factor promotes the survival of primary-cultured rat neuronal cells.  Neuroreport, 11(9): 2001-2006, 2000.

 

131.   Shinoura N., Yamamoto N., Asai A., Kirino T. and Hamada H.  Adenovirus-mediated Transfer of Fas Ligand Gene Augments Radiation-induced Apoptosis in U-373MG Glioma Cells.  Jpn. J. Cancer Res., 91(10): 1044-1050, 2000.

 

132.   Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Transduction of a Fiber-mutant Adenovirus for the HSVtk Gene Highly Augments the Cytopathic Effect towards Gliomas.  Jpn. J. Cancer Res., 91(10): 1028-1034, 2000.

 

133.   Hayashi S,. Dai-Kaku L., Namii Y., Kato T., Tokoro T., Kobayashi T., Yokoyama I., Hamada H. and Nakao A.  Effectiveness of adenovirus-mediated gene transfer with CTLA4Ig in allo and xeno-transplantation.  Transplant Proc., 32(7): 2520-2521, 2000.

 

134.   Hayashi S., Guang-Lin M., Yokoyama I., Namii Y., Hamada H. and Nakao A.  Adenovirus-mediated gene transfer of CTLA4Ig gene results in prolonged survival of heart allograft.  Transpl Int., 13 Suppl 1: S329-332, 2000.

 

135.   Seino K., Tun T., Ohshima N., Hamada H., Yoshino K., Ikeda S., Fukunaga K., Taniguchi H., Takada Y., Yuzawa K., Otsuka M., Todoroki T. and Fukao K.  Inhibition of CD95 ligand-mediated inflammation.  Transplant Proc., 32(7): 2038-2039, 2000.

 

136.   Shinoura N., Muramatsu Y., Asai A., Han S., Horii A., Kirino T. and Hamada H.  Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells.  Cancer Lett., 160(1): 67-73, 2000.

 

137.   Koyama F., Sawada H., Fujii H., Hamada H., Hirao T., Ueno M. and Nakano H.  Adenoviral-mediated transfer of escherichia coli uracil phosphoribosyltransferase (UPRT) gene to modulate the sensitivity of the human colon cancer cells to 5-fluorouracil.  Eur. J. Cancer, 36(18): 2403-2410, 2000.

 

138.   Kawamura K., Bahar R., Namba H., Seimiya M., Takenaga K., Hamada H., Sakiyama S. and Tagawa M.  Bystander effect in uracil phosphoribosyltransferase/5-fluorouracil-mediated suicide gene therapy is correlated with the level of intercellular communication.  Int. J. Oncology, 18(1): 117-120, 2001.

 

139.   Lin Hui Wang, Dian Wen Ju, Yinghao Sun, Qun Tao, Songxi Qian, Jing Mi, Hamada H., Xuetao Cao.  The potent antitumor effects of combined p16 gene and GM-CSF gene therapy through efficient induction of antitumor immunity.  J. Cancer Res. Clin. Oncol., 127: 101-108, 2001.

 

140.   Nagayama Y., Nishihara E., Namba H., Yokoi H., Hasegawa M., Mizuguchi H., Hayakawa T., Hamada H., Yamashita S. and Niwa M.  Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated Cre/loxP system.  Cancer Gene Ther., 8(1): 36-44, 2001.

 

141.   Wang LH., Ju DW., Sun Y., Tao Q., Qian S., Mi J., Hamada H. and Cao X.  The potent antitumor effects of combined p16 gene and GM-CSF gene therapy through efficient induction of antitumor immunity.  J Cancer Res Clin Oncol., 127(2): 101-108, 2001.

 

142.   Shinohara T., Miki T., Nishimura N., Nokihara H., Hamada H., Mukaida N. and Sone S.  Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53.  Cancer Res., 61(2): 673-678, 2001.

 

143.   Ding L-H., Iimura E., Saijo K., Hamada H. and Ohno T.  A speedy method to detect inserted DNA fragment in cell lines transfected with retrovirus vectors.  Cytotechnology, 34: 243-252, 2000.

 

144.   Sugibayashi R., Shimizu T., Suzuki T., Yamamoto N., Hamada H. and Takeda K.  Upregulation of p21 (WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.  Oncogene, 20(10): 1220-1228, 2001.

 

145.   Shimizu T., Shimada H., Ochiai T. and Hamada H.  Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracl phosphoribosyl-transferase and herpes simplex virus thymidine kinase).  Cancer Gene Therapy, 8(7): 512-521, 2001.

 

146.   Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Co-transduction of apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells.  Jpn J Cancer Res., 92(4): 467-474, 2001.

 

147.   Kato J., Fujikawa K., Kanda M., Fukuda N., Sasaki K., Takayama T., Kobune M., Takada K., Takimoto R., Hamada H., Ikeda T. and Niitsu Y.  A Mutation, in the Iron-Responsive Element of H Ferritin mRNA, Causing Autosomal Dominant Iron Overload.  Am. J. Hum. Genet., 69: 191-197, 2001.

 

148.   Ohashi M., Kanai F., Tateishi K., Taniguchi H., Marignani PA., Yoshida Y., Shiratori Y., Hamada H. and Omata M.  Target gene therapy for a-fetoprotein-producing hepatocellular carcinoma by E1B55K-attenuated adenovirus.  Biochem. Biophys. Res. Commun., 282: 529-535, 2001.

 

149.   Ohara N., Koyama H., Miyata T., Hamada H., Miyatake S-I., Akimoto M. and Shigematsu H.  Adenovirus-mediated ex vivo gene transfer of basic fibroblast growth factor promotes collateral development in a rabbit model of hind limb ischemia.  Gene Ther., 8: 837-845, 2001.

 

150.   Shinoura N., Sakurai S., Asai A., Kirino T., and Hamada H.  Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells.  Int. J. Cancer., 15:93(2): 252-261, 2001.

 

151.   Shinoura N., Sakurai S., Asai A., Kirino T. and Hamada H.  Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells.  Neurosurgery, 49(1): 177-186; discussion 186-187, 2001.

 

152.   Desaknai Sz., Lumniczky K., Hidvegi E.J., Hamada H. and Safrany G.  Brain tumor treatment with IL-2 and IL-12 producing autologous cancer cell vaccines.  Adv. Exp. Med. Biol., 495: 369-372, 2001.

 

153.   Nishimura S., Adachi M., Ishida T., Matsunaga T., Uchida H., Hamada H. and Imai K.  Adenovirus-mediated transfection of caspase-8 augments anoikis and inhibits peritoneal dissemination of human gastric carcinoma cells.  Cancer Res., 61(19): 7009-7014, 2001.

 

154.   Shinohara T., Nishimura N., Hanibuchi M., Nokihara H., Miki T., Hamada H. and Sone S.  Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice.  Int. J. Cancer, 94(1): 16-23, 2001.

 

155.   Nakamura H., Sekiguchi H., Akiyama S., Hamada H., Fujiwara M., Kasai Y., Ito K. and Nakao A.  Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene increases the sensitivity of esophageal cancer cells to 5-fluorouracil.  Surg. Today., 31(9): 785-790, 2001.

 

156.   Fujita N., Kagamu H., Yoshizawa H., Itoh K., Kuriyama H., Matsumoto N., Ishiguro T., Tanaka J., Suzuki E., Hamada H. and Gejyo F.  CD40 Ligand Promotes Priming of Fully Potent Antitumor CD4 (+) T Cells in Draining Lymph Nodes in the Presence of Apoptotic Tumor Cells.  J. Immunol., 15;167(10): 5678-5688, 2001.

 

157.   Ueno M., Koyama F., Yamada Y., Fujimoto H., Takayama T., Kamada K., Naito A., Hirao S., Mukogawa T., Hamada H. and Nakajima Y.  Tumor-specific chemo-radio-gene therapy for colorectal cancer cells using adenovirus vector expressing the cytosine deaminase gene.  Anticancer Res., 21(4A): 2601-2608, 2001.

 

158.   Matsuoka N., Ishii K., Akimoto M., Hamada H., Hashimoto N. and Miyatake SI.  Overexpression of bFGF and Bcl-xL with adenoviral vectors protects primarily cultured-neurons against glutamate insult.  Neurosurgery, 50(4): 857-863, 2002.

 

159.   Shinoura N., Furitsu T., Asai A., Kirino T. and Hamada H.  Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells.  Anticancer Res., 21(5): 3261-3268, 2001.

 

160.   Shimada H., Liu TL., Ochiai T., Shimizu T., Haupt Y., Hamada H., Abe T., Oka M., Takiguchi M. and Hiwasa T.  Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33 (ING1) in T.Tn human esophageal carcinoma cells.  Oncogene, 21(8): 1208-1216, 2002.

 

161.   Uchida H., Shinoura N., Kitayama J., Watanabe T., Nagawa H. and Hamada H.  Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells.  Biochem. Biophys. Res. Commun., 292(2): 347-354, 2002.

 

162.   Yamamoto S., Yoshida Y., Aoyagi M., Ohno K., Hirakawa K. and Hamada H.  Reduced transduction efficiency of adenoviral vectors expressing human p53 gene by repeated transduction into glioma cells in vitro.  Clin. Cancer Res., 8(3): 913-921, 2002.

 

163.   Nakamura T., Sato K. and Hamada H.  Effective Gene Transfer to Human Melanomas via Integrin-Targeted Adenoviral Vectors.  Hum. Gene Ther., 13(5): 613-626, 2002.

 

164.   Lumniczky K., Desaknai Sz., Mangel L., Szende B., Hamada H., Hidvegi E.J. and Safrany G.  Local tumor irradiation augments the antitumor effect of cytokine-producing autologous cancer cell vaccines in a murine glioma model.  Cancer Gene Ther., 9: 44-52, 2002.

 

165.   Xia DJ., Zhang WP., Zheng S., Wang J., Pan JP., Wang Q., Zhang LH., Hamada H. and Cao X.  Lymphotactin co transfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100.  Gene Ther., 9(9): 592-601, 2002.

 

166.   Shinoura N., Sakurai S., Shibasaki F., Asai A., Kirino T. and Hamada H.  Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas.  Br. J. Cancer, 86(4): 587-595, 2002.

 

167.   Kamata T., Hattori Y., Hamada H., Kizaki M., Terada M. and Ikeda Y.  Keratinocyte growth factor regulates proliferation and differentiation of hematopoietic cells expressing the receptor gene K-sam.  Exp. Hematol., 30(4): 297-305,2002.

 

168.   Akimoto M., Miyahara T., Arai J., Akimoto A., Hamada H., Yoshida Y. and Yoshimura N.  A new delivery system for 5-fluorouracil using prodrug and converting enzyme.  Br. J. Ophthalmol., 86(5): 581-586, 2002.

 

169.   Takahashi M., Sato T., Sagawa T., Lu Y., Sato Y., Iyama S., Yamada Y., Fukaura J., Takahashi S., Miyanishi K., Yamashita T., Sasaki K., Kogawa K., Hamada H., Kato J. and Niitsu Y.  E1B-55K-Deleted Adenovirus Expressing E1A-13S by AFP-Enhancer/Promoter Is Capable of Highly Specific Replication in AFP-Producing Hepatocellular Carcinoma and Eradication of Established Tumor.  Mol. Ther., 5 (5 Pt 1): 627-634, 2002.

 

170.   Sugibayashi R., Kiguchi Y., Shimizu T., Suzuki T., Hamada H. and Takeda K.  Up-regulation of p21 (WAF1/CIP1) levels leads to growth suppression of prostate cancer cell lines.  Anticancer Res., 22(2A): 713-719, 2002.

 

171.   Sakurai S., Sonoda Y., Koguchi E., Shinoura N., Hamada H. and Kasahara T.  Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G.  Biochem. Biophys. Res. Commun., 293: 174-181, 2002.

 

172.   Hoshida T., Sunamura M., Duda D.G., Egawa S., Miyazaki S., Shineha R., Hamada H., Ohtani H., Satomi S. and Matsuno S.  Gene Therapy for Pancreatic Cancer Using an Adenovirus Vector Encoding Soluble flt-1 Vascular Endothelial Growth Factor Receptor.  Pancreas, 25(2): 111-121, 2002.

 

173.   Sakurada A., Hamada H., Fukushige S., Yokoyama T., Yoshinaga K., Furukawa T., Sato S., Yajima A., Sato M., Fujimura S. and Horii A.  Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.  Int. J. Oncol., 15: 1069-1074, 1999.

 

174.   Nakamori M., Iwahashi M., Ueda K., Tsunoda T., Terasawa H., Hamada H. and Yamaue H.  Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with Cytosine deaminase / 5-fluorocytosine: preclinical consideration.  Jpn. J. Cancer Res., 93(6): 706-715, 2002.

 

175.   Satoh M., Masamune A., Sakai Y., Kikuta K., Hamada H. and Shimosegawa T.  Establishment and characterization of a simian virus 40-immortalized rat pancreatic stellate cell line.  Tohoku J. Exp. Med., 198(1): 55-69, 2002.

 

176.   Tanaka S., Takehashi M., Matoh N., Iida S., Suzuki T., Futaki S., Hamada H., Masliah E., Sugiura Y. and Ueda K.  Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.  J. Neurochem., 82(2): 305-315, 2002.

 

177.   Kambara H., Tamiya T., Ono Y., Ohtsuka S., Terada K., Adachi Y., Ichikawa T., Hamada H. and Ohmoto T.  Combined radiation and gene therapy for brain tumors with adenovirus-mediated transfer of cytosine deaminase and uracil phosphoribosyltransferase genes.  Cancer Gene Ther., 9(10): 840-845, 2002.

 

178.   Oonuma M., Sunamura M., Motoi F., Fukuyama S., Shimamura H., Yamauchi J., Shibuya K., Egawa S., Hamada H., Takeda K. and Matsuno S.  Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors.  Int. J. Cancer, 102(1): 51-59, 2002.

 

179.   Kawano Y., Kobune M., Yamaguchi M., Nakamura K., Ito Y., Sasaki K., Takahashi S., Nakamura T., Chiba H., Sato T., Matsunaga T., Azuma H., Ikebuchi K., Ikeda H., Kato J., Niitsu Y. and Hamada H.  Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subnit (hTERT)-transfected human stromal cells.  Blood, 101(2): 532-540, 2003.

 

180.   Uchida H., Shinoura N., Kitayama J., Watanabe T., Nagawa H. and Hamada H.  5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus- mediated transfer of caspase-8 in DLD-1 colon cancer cells.  J. Gene Med., 5(4): 287-299, 2003.

 

181.   Huang X., Zhang W., Wakimoto H., Hamada H. and Cao X.  Adenovirus-mediated tissue-specific cytosine deaminase gene therapy for human hepatocellular carcinoma with different AFP expression levels.  J. Exp. Ther. Oncol., 2(2): 100-106, 2002.

 

182.   Tsuda H., Wada T., Ito Y., Uchida H., Dehari H., Nakamura K., Sasaki K., Kobune M., Yamashita T. and Hamada H.  Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector.  Mol. Ther., 7(3): 354-365, 2003.

 

183.   Nakamura T., Sato K. and Hamada H.  Reduction of natural adenovirus tropism to the liver by both ablation of fiber-Coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber.  J. Virol., 77(4): 2512-2521, 2003.

 

184.   Ugai H., Suzuki E., Inabe K., Murata T., Hamada H. and Yokoyama KK.  Spontaneous mutations in the human gene for p53 in recombinant adenovirus during multiple passages in human embryonic kidney 293 cells.  Biochem. Biophys. Res. Commun., 300(2): 448-456, 2003.

 

185.   Dehari H., Ito Y., Nakamura T., Kobune M., Sasaki K., Yonekura N, Kohama G. and Hamada H.  Enhanced antitumor effect of RGD fiber-modified adenovirus for gene therapy of oral cancer.  Cancer Gene Therapy, 10(1): 75-85, 2003.

 

186.   Miyagi T., Koshida K., Hori O., Konaka H., Katoh H., Kitagawa Y., Mizokami A., Egawa M., Ogawa S., Hamada H. and Namiki M.  Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system.  J. Gene Med., 5(1): 30-37, 2003.

 

187.   Kuwahara I., Ikebuchi K., Hamada H., Niitsu Y., Miyazawa K., Ohyashiki K., Fujisawa H. and Furukawa K.  Changes in N-glycosylation of human stromal cells by telomerase expression.  Biochem. Biophys. Res. Commun., 301(2): 293-297, 2003.

 

188.   Koyama F., Fujii H., Mukogawa T., Ueno M., H. Hamada, Ishikawa H., Doi S., Nakao T., Matsumoto H., Shimatani H., Takeuchi T. and Nakajima Y.  Chemo-radio-gene therapy for colorectal cancer cells using the Escherichia coli uracil phosphoribosyltransferase gene.  Anticancer Res.(23), 1343-1348, 2003.

 

189.   Takikawa H., Mafune K., Hamada H., Nettelbeck D. M., Muller R., Makuuchi M. and Kaminishi M.  An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma.  Int. J. Oncol., 22(5): 1051-1056, 2003.

 

190.   Desaknai S., Lumniczky K., Esik O., Hamada H. and Safrany G.  Local tumour irradiation enhances the anti-tumour effect of a double-suicide gene therapy system in a murine glioma model.  J. Gene Med., 5(5): 377-385, 2003.

 

191.   Huang J., Ito Y., Kobune M., Sasaki K., Nakamura K., Dehari H., Takahashi K., Uchida H., Kato K. and Hamada H.  Myocardial injection of CA promoter-based plasmid mediates efficient transgene expression in rat heart.  J. Gene Med., 5(10): 900-908. 2003.

 

192.   Yamauchi A., Ito Y., Morikawa M., Kobune M., Huang J., Sasaki K., Takahashi K., Nakamura K., Dehari H., Niitsu Y., Abe T. and Hamada H.  Pre-administration of angiopoietin-1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model.  J. Gene Med., 5(11): 994-1004. 2003.

 

193.   Ninomiya M., Koyama H., Miyata T., Hamada H., Miyatake S., Shigematsu H. and Takamoto S.  Ex vivo gene transfer of basic fibroblast growth factor improves cardiac function and blood flow in a swine chronic myocardial ischemia model.  Gene Ther., 10(14): 1152-1160, 2003.

 

194.   Takahashi K., Ito Y., Morikawa M., Kobune M., Huang J., Tsukamoto M., Sasaki K., Nakamura K., Dehari H., Ikeda K., Uchida H., Hirai S., Abe T. and Hamada H.  Adenoviral delivered angiopoietin-1 reduces the infarction and attenuates the progression of cardiac dysfunction in the rat model of acute myocardial infarction.  Mol. Ther., 8(4): 584-592, 2003.

 

195.   Kobune M., Kawano Y., Ito Y., Chiba H., Nakamura K., Tsuda H., Sasaki K., Dehari H., Uchida H., Honmou O., Takahashi S., Bizen A., Takimoto R., Matsunaga T., Kato J., Kato K., Houkin K., Niitsu Y. and Hamada H.  Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells.  Exp. Hematol., 31(8): 715-722, 2003.

 

196.   Fukuda K., Abei M., Ugai H., Seo E., Wakayama M., Murata T., Todoroki T., Tanaka N., Hamada H. and Yokoyama K.  E1A, E1B Double-restricted Adenovirus for Oncolytic Gene Therapy of Gallbladder Cancer.  Cancer Res., 63(15): 4434-4440. 2003.

 

197.   Kobayashi T., Yamada Y., Nagashima M., Seki S., Tsutsuura M., Ito Y, Sakuma I., Hamada H., Abe T. and Tohse N.  Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes.  J. Mo.l Cell. Cardiol., 35(9): 1073-1082. 2003.

 

198.   Hagiwara S., Nakamura K., Hamada H., Sasaki K., Ito Y., Kuribayashi K., Sato T., Sato Y., Takahashi M., Kogawa K., Kato J., Terui T., Takayama T., Matsunaga T., Taira K. and Niitsu Y.  Inhibition of type I procollagen production by tRNAVal CTE-HSP47 ribozyme.  J. Gene. Med., 5(9): 784-794. 2003.

 

199.   Huang J., Ito Y., Morikawa M., Uchida H., Kobune M., Sasaki K., Abe T., Hamada H.  Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury.  Biochem. Biophys. Res. Commun., 311(1): 64-70, 2003.

 

200.   Kurozumi K., Nakamura K., Tamiya T., Kawano Y., Kobune M., Hirai S., Uchida H., Sasaki K., Ito Y., Kato K., Honmou O., Houkin H., Date I., and Hamada H.   BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model.  Mol. Ther,. 9(2): 189-97, 2004.

 

201.   Nakamura K., Ito Y., Kawano Y., Kurozumi K., Kobune M., Tsuda H., Bizen A., Honmou O., Niitsu Y. and Hamada H.   Anti-tumor effect of genetically engineered mesenchymal stem cells in a rat glioma model.  Gene Ther., 11(14): 1155-1164, 2004.

 

202.   Ishii S., Koyama H., Miyata T., Nishikage S., Hamada H., Miyatake S., Shigematsu H.  Appropriate control of ex vivo gene therapy delivering basic fibroblast growth factor promotes successful and safe development of collateral vessels in rabbit model of hind limb ischemia.  J. Vasc. Surg., 39(3): 629-638, 2004.

 

203.   Ono I., Yamashita T., Hida T., Jin H.Y., Ito Y., Hamada H., Akasaka Y., Ishii T., Jimbow K.  Combined administration of basic fibroblast growth factor protein and the hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds.  Wound Repair Regen., 12(1): 67-79, 2004.

 

204.   Kondoh K., Koyama H., Miyata T., Takato T., Hamada H., Shigematsu H.  Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor.  Cardiovasc. Res., 61(1): 132-142, 2004.

 

205.   Kurozumi K., Tamiya T., Ono Y., Otsuka S., Kambara H., Adachi Y., Ichikawa T., Hamada H., Ohmoto T.  Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus.  J. Neurooncol., 66(1-2): 117-127, 2004.

 

206.   Okada T., Caplen N.J., Ramsey W.J., Onodera M., Shimazaki K., Nomoto T., Ajalli R., Wildner O., Morris J., Kume A., Hamada H., Blaese R.M., Ozawa K.  In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.  J. Gene Med., 6(3): 288-299, 2004.

 

207.   Yasuhara T., Shingo T., Kobayashi K., Takeuchi A., Yano A., Muraoka K., Matsui T., Miyoshi Y., Hamada H., Date I.  Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease.  Eur. J. Neurosci., 19(6): 1494-1504, 2004.

 

208.   Kobune M., Ito Y., Kawano Y., Sasaki K., Uchida H., Nakamura K., Dehari H., Chiba H., Takimoto R., Matsunaga T., Terui T., Kato J., Niitsu Y., Hamada H.  Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta-2m-/- repopulating cells.  Blood, 104(4): 1002-1009, 2004.

 

209.   Ono I., Yamashita T., Jin H.Y., Ito Y., Hamada H., Akasaka Y., Nakasu M., Ogawa T., Jimbow K.  Combination of porous hydroxyapatite and cationic liposomes as a vector for BMP-2 gene therapy.  Biomaterials, 25(19): 4709-4718, 2004.

 

210.   Sako A., Kitayama J., Koyama H., Ueno H., Uchida H., Hamada H., Nagawa H.  Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer.  Cancer. Res., 64(10): 3624-3628, 2004.

 

211.   Nishikage S., Koyama H., Miyata T., Ishii S., Hamada H., Shigematsu H.  In vivo electroporation enhances plasmid-based gene transfer of basic fibroblast growth factor for the treatment of ischemic limb.  J. Surg. Res., 120(1): 37-46, 2004.

 

212.   Ono I., Yamashita T., Hida T., Jin H.Y., Ito Y., Hamada H., Akasaka Y., Ishii T., Jimbow K.  Local administration of hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds.  J. Surg. Res., 120(1): 47-55, 2004.

 

213.   Uchida H., Tanaka T., Sasaki K., Kato K., Dehari H., Ito Y., Kobune M., Miyagishi M., Taira K., Tahara H., Hamada H.  Adenovirus-Mediated Transfer of siRNA against Survivin Induced Apoptosis and Attenuated Tumor Cell Growth in Vitro and in Vivo.  Mo.l Ther., 10(1): 162-171, 2004.

 

214.   Tani K., Azuma M., Nakazaki Y., Oyaizu N., Hase H., Ohata J., Takahashi K., OiwaMonna M., Hanazawa K., Wakumoto Y., Kawai K., Noguchi M., Soda Y., Kunisaki R., Watari K., Takahashi S., Machida U., Satoh N., Tojo A., Maekawa T., Eriguchi M., Tomikawa S., Tahara H., Inoue Y, Yoshikawa H, Yamada Y, Iwamoto A, Hamada H, Yamashita N, Okumura K., Kakizoe T., Akaza H., Fujime M., Clift S., Ando D., Mulligan R., Asano S.  Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings.  Mol. Ther., 10(4): 799-816, 2004.

 

215.   Sagawa T., Takahashi M., Sato T., Sato Y., Lu Y., Sumiyoshi T., Yamada Y., Iyama S., Fukaura J., Sasaki K., Hamada H., Miyanishi K., Takayama T., Kato J., Niitsu Y.  Prolonged survival of mice with multiple liver metastases of human colon cancer by intravenous administration of replicable E1B-55K-deleted adenovirus with E1A expressed by CEA promoter.  Mol. Ther., 10(6): 1043-1050, 2004.

 

216.   Chiba H., Kobune M., Kato J., Kawano Y., Ito Y., Nakamura K., Asakura S., Hamada H., Niitsu Y.  Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells.  Exp. Hematol., 232(12): 1194-1203, 2004.

 

217.   Kurozumi K., Nakamura K., Tamiya T., Kawano Y., Ishii K., Kobune M., Hirai S., Uchida H., Sasaki K., Ito Y., Kato K., Honmou O., Houkin K., Date I., Hamada H.  Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model.  Mol. Ther., 11(1): 96-104, 2005.

 

218.   Yasui H., Adachi M., Hamada H., Imai K.  Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand.  Int. J. Oncol., 26(2): 537-544, 2005.

 

219.   Huang J., Nakamura K., Ito Y., Uzuka T., Morikawa M., Hirai S., Tomihara K., Tanaka T., Masuta Y., Ishii K., Kato K., Hamada H.  Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rat.  Circulation, 112(1): 76-83, 2005.

 

220.   Seo E., Abei M., Wakayama M., Fukuda K., Ugai H., Murata T., Todoroki T., Matsuzaki Y., Tanaka N., Hamada H., Yokoyama K.K.  Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration.  Cancer Res., 65(2): 546-552, 2005. 

 

221.   Yasuhara T., Shingo T., Muraoka K., Wen Ji Y., Kameda M., Takeuchi A., Yano A., Nishio S., Matsui T., Miyoshi Y., Hamada H., Date I.  The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model.  Brain Res., 1038(1): 1-10, 2005.

 

222.   Kobune M., Kawano Y., Kato J., Ito Y., Chiba H., Nakamura K., Fujimi A., Matsunaga T., Hamada H., Niitsu Y.  Expansion of CD34+ cells on telomerized human stromal cells without losing erythroid-differentiation potential in a serum-free condition.  Int. J. Hematol., 81(1): 18-25, 2005.

 

223.   Sato Y., Araki H., Kato J., Nakamura K., Kawano Y., Kobune M., Sato T., Miyanishi K., Takayama T., Takahashi M., Takimoto R., Iyama S., Matsunaga T., Ohtani S., Matsuura A., Hamada H., Niitsu Y.  Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.  Blood, 106(2): 756-763, 2005.

 

224.   Ugai H., Yamasaki T., Hirose M., Inabe K., Kujime Y., Terashima M., Liu B., Tang H., Zhao M., Murata T., Kimura M., Pan J., Obata Y., Hamada H., Yokoyama K. K.  Purification of infectious adenovirus in two hours by ultracentrifugation and tangential flow filtration.  Biochem. Biophys Res. Commun., 331(4): 1053-1060, 2005.

 

225.   Tsuda H., Wada T., Yamashita T., Hamada H.  Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber-mutant adenoviral BMP2 gene.  J. Gene Med., 7(10): 1322-1334, 2005.

 

226.   Ugai H., Murata T., Nagamura Y., Ugawa Y., Suzuki E., Nakata H., Kujime Y., Inamoto S., Hirose M., Inabe K., Terashima M., Yamasaki T., Liu B., Nakade K., Pan J., Kimura M., Saito I., Hamada H., Obata Y., Yokoyama K.K.  A database of recombinant viruses and recombinant viral vectors available from the RIKEN DNA bank.  J. Gene Med., 7(9): 1148-1157, 2005.

 

227.   Yasuhara T., Shingo T., Muraoka K., Kameda M., Agari T., Wen Ji Y., Hayase H., Hamada H., Borlongan CV., Date I.  Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain. Res., 1053(1-2): 10-18, 2005.

 

228.   Linwong W., Hirasawa N., Aoyama S., Hamada H., Saito T., Ohuchi K.  Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.  Br. J. Pharmacol., 145(6): 818-828, 2005.

 

229.   Ichiba M., Shimomura T., Murai R., Hashiguchi K., Saeki T., Yoshida Y., Kanbe T., Tanabe N., Tsuchiya H., Miura N., Tajima F., Kurimasa A., Hamada H., Shiota G.  Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts.  Biochem. Biophys. Res. Commun., 335(3): 723-729, 2005.

 

230.   Yano A., Shingo T., Takeuchi A., Yasuhara T., Kobayashi K., Takahashi K., Muraoka K., Matsui T., Miyoshi Y., Hamada H., Date I.  Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia.  J. Neurosurg., 103(1): 104-114, 2005.

 

231.   Harada N., Maniwa Y., Yoshimura M., Nagata M., Hamada H., Yokono K., Okita Y.  E1B-deleted adenovirus replicates in p53-deficient lung cancer cells due to the absence of apoptosis.  Oncol .Rep., 14(5): 1155-1163, 2005.

 

232.   Ugai H., Inabe K., Yamasaki T., Murata T., Obata Y., Hamada H., Yokoyama K.K.  Accumulation of infectious mutants in stocks during the propagation of fiber-modified recombinant adenoviruses.  Biochem. Biophys. Res. Commun., 337(3): 806-814, 2005.

 

233.   Nomura T., Honmou O., Harada K., Houkin K., Hamada H., Kocsis J.D.  I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat.  Neuroscience, 136(1): 161-169, 2005.

 

234.   Kusaka N., Sugiu K., Tokunaga K., Katsumata A., Nishida A., Namba K., Hamada H., Nakashima H., Date I.  Enhanced brain angiogenesis in chronic cerebral hypoperfusion after administration of plasmid human vascular endothelial growth factor in combination with indirect vasoreconstructive surgery.  J. Neurosurg., 103(5): 882-890, 2005.

 

235.   Kobune M., Kato J., Chiba H., Kawano Y., Tanaka M., Takimoto R., Hamada H., Niitsu Y.  Telomerized human bone marrow-derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture.  Exp. Hematol., 33(12): 1544-1553, 2005.

 

236.   Honma T., Honmou O., Iihoshi S., Harada K., Houkin K., Hamada H., Kocsis J.D.  Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat.  Exp. Neurol.,199(1): 56-66, 2006.

 

237.   Saito Y., Sunamura M., Motoi F., Abe H., Egawa S., Duda D.G., Hoshida T., Fukuyama S., Hamada H., Matsuno S.  Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.  Cancer Gene Ther., 13： 242-252, 2006.

 

238.   Nakamura T., Moriguchi R., Kogure K., Minoura A., Masuda T., Akita H., Kato K., Hamada H., Ueno M., Futaki S. and Harashima H.  Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells.  Biol. Pharm. Bull., 29(6): 1290-1293, 2006.

 

239.   Kawano Y., Kobune M., Chiba H., Nakamura K., Takimoto R., Takada K., Ito Y., Kato J., Hamada H., Niitsu Y.  Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells.  Exp. Hematol., 34(2): 150-158, 2006.

 

240.   Tanaka T., Huang J., Hirai S., Kuroki M., Kuroki M., Watanabe N., Tomihara K., Kato K. and Hamada H.  Carcinoembryonic antigen targeted selective genetherapy for gastric cancer through FZ33 fiber-modified adenovirus vectors.  Clinical Cancer Research, 12(12): 3803-3813, 2006.

 

241.   Szatmari T., Lumniczky K., Desaknai S., Stephane Trajcevski S., Hidvegi J.E., Hamada H. and Safrany G.  Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy.  Cancer Sci., 97(6): 546-553, 2006.

 

242.   Liu H., Honmou O., Harada K., Nakamura K., Houkin K., Hamada H., Kocsis J.D.  Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain, Oct; 129(Pt 10): 2734-45, 2006.

 

243.   Matsunaga T., Tanaka I., Kobune M., Kawano Y., Tanaka M., Kuribayashi K., Iyama S., Sato T., Sato Y., Takimoto R., Takayama T., Kato J., Ninomiya T., Hamada H., Niitsu Y.  Ex vivo large scale generation of human platelets from cord blood CD34+cells.  Stem Cells:2877-2887, 2006

 

244.   Horita Y, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD.  Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat.  J. Neurosci. Res., 84(7): 1495-1504, 2006.

 

245.   Kim S, Honmou O, Kato K, Nonaka T, Houkin K, Hamada H, Kocsis JD.  Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells. Brain Res., 2006 [Epub ahead of print]

 

246.   Wang H, Satoh M, Abe H, Sunamura M, Moriya T, Ishidoya S, Saito S, Hamada H, Arai Y.  Oncolytic viral therapy by bladder instillation using an E1A, E1B double-restricted adenovirus in an orthotopic bladder cancer model. Urology, 68(3): 674-681, 2006.

 

247.   .Kato K, Chu P, Takahashi S, Hamada H, Kipps TJ.  Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells.  Exp. Hematol., 35(3): 434-442, 2007

 

248.   Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I.  p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.  Nature, 446(7134): 444-448, 2007

 

249.   Tomihara K, Kato K, Masuta Y, Nakamura K, Tanaka T, Hiratsuka H, Hamada H.  Gene transfer of the CD40-ligand to human dendritic cells induces NK-mediated antitumor effects against human carcinoma cells.  Int. J. Cancer, 120(7): 1491-1498, 2007

 

250.   Yamaguchi M, Azuma H, Fujihara M, Hamada H, Ikeda H.  Generation of a considerable number of functional mast cells with a high basal level of Fc?RI expression from cord blood CD34＋ cells by co-culturing them with bone marrow stromal cell line under serum-free conditions.  Scandinavian journal of Immunology, 65: 581-588, 2007

 

251.   Ukai R, Honmou O, Harada K, Houkin K, Hamada H, Jeffery D.Kocsis.  Mesenchymal stem cells derived from peripheral blood protects against ischemia.  Journal of Neurotrauma 24(3):508-520, 2007

 

252.   Suzuki K, Nakamura K, Kato K, Hamada H, Tsukamoto T.  Exploration of target molecules for prostatecancer gene therapy.  The Prostate 67:1163-1173, 2007

 

253.   Onda T, Honmou O, Harada K, Houkin K, Hamada H, Jeffery D.K.  Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified h MSCs after cerebral ischemia.  Journal of Cerebral Blood Flow & Metabolism:1-12, 2007

 

254.   Masuta Y, Kato K, Tomihara K, Nakamura K, Sasaki K, Takahashi S, Hamada H.  Gene transfer of noncleavable cell surface mutants of human CD154 induces the immune response and diminishes systemic inflammatory reactions.  J.Immunother.,30(7): 694-704, 2007

 

255.   Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Uqai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama K.  E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers.  Clin. Cancer Res. 13(10): 3043-3050, 2007

 

256.   Kameda M, Shingo T, Takahashi K, Muraoka K, Kurozumi K, Yasuhara T, Maruo T, Tsuboi T, Uozumi T, Matsui T, Miyoshi Y, Hamada H, Date I.  Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia.  Eur J Neurosci.: 26(6):1462-1478, 2007

 

257.   Satoh M, Wang H, Ishidoya S, Abe H, Moriya T, Hamada H, Arai Y.
Oncolytic virotherapy for prostate cancer by E1A, E1B mutant adenovirus.  Urology. : 70(6):1243-1248, 2007

 

258.   Tomihara K, Kato K, Masuta Y, Nakamura K, Uchida H, Sasaki K, Tanaka T, Huang J, Hiratsuka H, Hamada H.  Gene transfer of CD40-ligand to dendritic cells　stimulates interferon-? production to induce growth arrest and apoptosis of tumor cells.  Gene Therapy 15: 203-213, 2008

 

259.   Oku E, Kanaji T, Takata Y, Oshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K, Yakushiji K, Yoshimoto K, Ogata H, Hamada H, Izuhara K, Sata M, Okamura T.　　Periostin and bone marrow fibrosis.   Int J Hematol: 2008

 

260.   Sakata M, Yasuda H, Moriyama H, Yamada K, Kotani R, Kurohara M, Okumachi Y, Kishi M, Arai T, Hara K, Hamada H, Yokono K, Nagata M.       Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NODislets adenovirally transduced with immunomodulating molecules.   Diabetes Research and Clinical Practice 80: 352-359, 2008

 

261.   Fujimi A, Matsunaga T, Kobune M, Kawano Y, Nagaya T, Tanaka I, Iyama S, Hayashi T, Sato T, Miyanishi K, Sagawa T, Sato Y, Takimoto R, Takayama T, Kato J, Gasa S, Sakai H, Tsuchida E, Ikebuchi K, Hamada H, Niitsu Y.  Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages.　 Int J Hematol 87: 339-350 , 2008

 

262.   Sasaki K, Kogure K, Chaki S, Nakamura Y, Moriguchi R, Hamada H, Danev R, Nagayama K, Futaki S, Harashima H.  An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives.  Anal Bioanal Chem. , 391(8): 2717-27, 2008

 

263.   Sagawa T, Yamada Y, Takahashi M, Sato Y, Kobune M, Takimoto R, Fukaura J, Iyama S, Sato T, Miyanishi K, Matsunaga T, Takayama T, Kato J, Sasaki K, Hamada H, Niitsu Y.  Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice.  Hepatology 48(3): 828-40, 2008

 

264.   Ishii K, Nakamura K, Kawaguchi S, Li R, Hirai S, Sakuragi N, Wada T, Kato K, Yamashita T, Hamada H.  Selective gene transfer into neurons via Na,K-ATPase beta1. Targeting gene transfer with monoclonal antibody and adenovirus vector.  J Gene Med. : 10(6):597-609, 2008

 

265.   Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka Y, Hamada H, Usui T, Mochizuki M, Yamagami S. Human corneal endothelial cells expressing programmed death-ligand 1(PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism.  Invest Ophthalmol Vis Sci.: 2008  [Epub ahead of print]

 

266.    Fukuda K, Abei M, Ugai H, Kawashima R, Seo E, Wakayama M, Murata T, Endo S, Hamada H, Hyodo I, Yokoyama KK.　E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer.　Cancer Gene Ther.： 2008  [Epub ahead of print]　

 

 

業績目録　その２　欧文総説

 

その２の１　学術雑誌に掲載された英文総説

1）   Kanai, F., Hamada, H., Shiratori, Y., and Omata, M.  Adenovirus-mediated prodrug-enzyme therapy for cancer.  The Cancer Journal 10 (6): 301-305, 1997 (Review).

 

2）   Shinoura N, Hamada H.  Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells.  Curr Gene Ther. 2003 Apr; 3(2):147-153. (Review)

 

3）   Sunamura M, Hamada H, Motoi F, Oonuma M, Abe H, Saitoh Y, Hoshida T, Ottomo S, Omura N, Matsuno S. Oncolytic virotherapy as a novel strategy for pancreatic cancer. Pancreas. 28: 326-329, 2004.

 

4）   Hamada H, Kobune M, Nakamura K, Kawano Y, Kato K, Honmou O, Houkin K, Matsunaga T, Niitsu Y. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci. 96(3): 149-156, 2005.

 

5）   Tanaka T, Kuroki M, Hamada H, Kato K, Kinugasa T, Shibaguchi H, Zhao J, Kuroki M. Cancer-targeting gene therapy using tropism-modified adenovirus. Anticancer Res.,27(6A): 3679-3684,  2007

 

6）   Tanaka T, Hamada H, Kuroki M, Kato K, Zhao J, Kinugasa T, Shibaguchi H, Kuroki M.  Application of antibody for targeting of cancer gene therapy.  Current Trends in Immunology 8: 2007

 

7）   Nakamura K, Kato K, Tanaka T, Hamada H: Targeting vectors for cancer gene therapy. 21st Century's Center of Excellence Program of Japanease Ministry of Education and Science, Gene therapy 2007, 86-94, 2007.

 

その２の２　国際学会の Proceedingsなどに掲載された英文総説（論文形式のもの）（アブストラクトだけのものは除く）

 

8）    Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., and Mulligan R.C.  Prospects for the immunotherapy of cancer using genetically modified tumor cells., pp.22-29, in Clinical Pharmacology Vol. 9: Frontiers in Biomedical Research, D  Hartmann, Y. Furuichi, and J. Dews (eds), W. Zuckschwerdt Verlag, Munich, 1993. (Review)

 

9）    Hanada, K., Wakimoto, H., Abe, J., and Hamada, H. Strategies for immunogene therapy against cancer.  in Cancer Chemotherapy: Challenges for the Future, vol. 9,  Kimura, K. et al. eds. pp73-80, (International Congress series 1078)  Excerpta Medica, Ltd., Tokyo 1994. (Review)

 

10）   Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., and Mulligan R.C.  Granulocyte-macrophage colony-stimulating factor-based cancer vaccines. in  Cancer Chemotherapy: Challenges for the Future, vol. 9,  Kimura, K. et al. eds. pp55-62, (International Congress series 1078) Excerpta Medica, Ltd., Tokyo 1994. (Review)

 

11）   Hamada, H. Tumor vaccines expressing cytokine genes: Combination with adoptive immunogene therapy for cancer.  Proc. Hiroshima Cancer Seminar, 4, 17-20, 1994. (Review)

 

12）   Abe, J., Wakimoto, H., Yoshida, Y., Okabe, S., Tsunoda, R., Aoyagi, M., Hirakawa, K. and Hamada, H.  Adoptive immunotherapy with cytokine-gene-modified cytotoxic T lymphocytes.  pp.174-189, in  S. Ikehara, F. Takaku, and R.A. Good (eds.) Bone Marrow Transplantation: Basic and Clinical Studies, Springer Verlag, Tokyo, 1996. (Review)

 

13）   Tanaka T, Hamada H, Kuroki Mo, Kato K, Kinugasa T, Shibaguchi H, Kuroki Ma: Targeting Strategies by Coupling of Adenovirus Vector and Antibody for Cancer Gene Therapy. Recent Development in Gene Therapy (J. Xiang, ed.), TRANSWORLD RESERCH NETWORK, Kerala, pp. 319-326. 2007.

 

 

 

業績目録　その３　欧文著書　（共著）

 

1） Tsuruo, T., and Hamada, H.  Therapeutic implication of monoclonal antibodies against multidrug-resistant tumor cells.  pp109-126, in "Therapeutic Monoclonal Antibodies", Borrebaeck, C.A.K., and Larrick, J.W., ed., Stockton Press, New York, 1990. (Review)

 

2） Hamada, H., and Tsuruo, T. Growth inhibition of multidrug-resistant cells by monoclonal antibodies against P-glycoprotein. pp.373-391 in "Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells" ed. by I. B. Roninson, Plenum Press, 1991. (original data)

 

3） Yoshida, Y., and Hamada, H.  Transcriptional and promoter targeting through recombinant adenoviral vectors. as a chapter in a book, P. Seth ed.  “Human adenoviruses: from basic science to clinical applications”. R.G. Landes, Austin, Texas.  pp191-200, 1999. (Review)

 

4） Kanai, F., Ohashi, M., Tateishi, K., Kawakami, T., Shiratori, Y.,  Hamada, H.  and Omata, M.  Gene therapy for gastrointestinal and liver cancer. pp153-162,  in  N. Niho, ed. “Molecular and Genetic Approaches to Diseases - Immunology, Hematology, Oncology -”. Kyushu University Press, Fukuoka, Japan, 1998.  (Review)

 

5） Kanai, F., Ohashi, M., Marignani, P.A., Shiratori, Y.,  Hamada, H.  and Omata, M.  Adenovirus-mediated drug-sensitivity gene therapy for hepatocellular carcinoma.  Methods in Molecular Medicine, vol. 45: 257-269. in Hepatocellular Carcinoma Methods and Protocols, Edited by N.A. Habib, Humana Press Inc., Totowa, NJ, 2001. (Review)

 

6) Hamada H. Gene-modified mesenchymal stem cells as cytoreagents for regenerative therapy.  Pp117-138 in Stem Cell Repair and Regeneration ch09.  N. Habib et al. eds., Imperial College Press, 2005, London. (Review)

 

                                                                                                               

業績目録　その４　邦文著書（分担執筆）

 

1）    濱田洋文（分担執筆）癌遺伝子治療のストラテジー・癌免疫からのアプローチ、第10回「大学と科学」公開シンポジウム組織委員会編　  遺伝子治療・新しい治療への期待：pp88-98、クバプロ 1996

 

2）    脇本浩明、濱田洋文（分担執筆）遺伝子導入法・レトロウイルスベクター法

編著　浅野茂隆　　遺伝子治療ーその臨床展開と将来：pp33-42、真興交易医書出版部 1997

 

3）    濱田洋文（分担執筆）ウィルスベクター・レトロウイルスベクター　　日本遺伝子治療学会編集：遺伝子治療開発研究ハンドブック　第３章　導入技術、pp332-341、エヌ・ティー・エス、 1999

（注：　これの英語版 ”retrovirus vector” は、理化学研究所ホームページより公開, 2001）

 

4）    濱田洋文（分担執筆）遺伝子治療　pp783-784　尾形悦郎・小林登編集：百科・家庭の医学、主婦と生活社、1995、改訂・大活字版 1999

 

5）    濱田洋文（分担執筆）遺伝子治療　　日本動物細胞工学会編集：動物細胞工学ハンドブック、朝倉書店

 

6）    濱田洋文（分担執筆）制限増殖アデノウイルスベクター、癌の遺伝子治療への応用pp61-74、谷憲三朗、浅野茂隆編、遺伝子治療の最前線　羊土社、2001年

 

7）    濱田洋文　（分担執筆）ヒトへの核酸・遺伝子導入の方法と注意点　　　多比良和誠編　遺伝子機能破壊実験法　実験医学　ザ・プロトコールシリーズ　2001、羊土社

 

8）    濱田洋文　（分担執筆）消化器癌の遺伝子治療　　　木村・藤盛・加藤、編　「消化器癌のサーベイランス」　pp309-314、新興医学出版社、東京　2003。

 

9)      濱田洋文　（分担執筆）　ウイルスを用いた遺伝子導入法　pp236-244：　吉田陽子濱田洋文、アデノウイルス　pp236-238；　柴垣直孝、濱田洋文、BOSC23細胞を用いたレトロウイルス遺伝子導入法pp239-241；　花田賢一、濱田洋文、レトロウイルスcDNAライブラリーを用いた膜タンパク質の発現クローニング法、pp242-244。　小池、関谷、近藤、編　分子生物学プロトコール（改訂第2版）、南江堂、平成11年

 

10)    濱田洋文　（分担執筆）　免疫沈降を巡る今昔物語、pp228-230、大塚癌研想い出集、大塚癌研想い出集　編集委員会　発行、2005年3月25日、東京

 

11)     増田ゆかり、加藤和則、濱田洋文、　（分担執筆）　遺伝子治療と再生医療、pp115-124、討論pp125-127、次世代の血液製剤を考える、池田久実編、エフ・コピント・富士書院　刊行、平成15年6月30日

 

 

 

業績目録　その５　邦文総説

 

1)    濱田洋文、鶴尾隆　　抗癌剤耐性・基礎から臨床へ・多剤耐性特異的タンパクの発現と機能　癌と化学療法16(３) PART II：585-591、1989

 

2)    濱田洋文　　レトロウイルス・ベクターを用いた遺伝子治療法の開発　実験医学11(1)：69-74、羊土社 1993

 

3)    濱田洋文　　分子病態からみた病型分類・白血病細胞における薬剤耐性遺伝子の発現　medicina 30(4)：615-617、医学書院 1993

 

4)    脇本浩明、阿部純子、青柳傑、平川公義、濱田洋文　　外科手術摘除後の残存腫瘍を標的とした遺伝子治療法の併用による悪性脳腫瘍根治治療法の開発　　　がん治療のあゆみ13：121-127、癌と化学療法社 1994

 

5)    阿部純子、濱田洋文　　免疫療法による癌の遺伝子治療　　　実験医学12(15)増刊：　122(1892)-127(1897)、羊土社 1994

 

6)    花田賢一、濱田洋文　　遺伝子治療ー最近の展開・サイトカイン遺伝子を使った癌の遺伝子治療　実験医学　12(3)２月号：52(340)-56(344)、羊土社 1994

 

7)    脇本浩明、濱田洋文　　遺伝子治療の基礎技術・遺伝子導入法・レトロウイルスベクター　蛋白質 核酸 酵素40(17)：26(2508)-31(2513)、共立出版 1995

 

8)    脇本浩明、濱田洋文　　癌関連遺伝子の導入法・癌ワクチン療法　編集　横田淳、山本雅　　　実験医学別冊・分子生物学的アプローチによる癌研究プロトコール：135-141、羊土社1995

 

9)    山口聰、濱田洋文　　遺伝子治療の理論・サイトカイン遺伝子を用いた癌に対する免疫遺伝子治療　　医学のあゆみ 175(9)：690-694、1995

 

10)   花田賢一、濱田洋文　　サイトカインを用いた癌の遺伝子治療　　免疫　Immunology Frontier 5(3)：27(191)-32(196)、メディカルレビュー社 1995

 

11)   濱田洋文　　がん遺伝子治療の展望　　現代化学１１月：20-23、東京化学同人 1996

 

12)  脇本浩明、濱田洋文　　ウイルスベクターの作製法・レトロウイルスベクター・高力価レトロウイルスベクターの作製法　　編集　島田隆、斎藤泉、小澤敬也　　実験医学別冊・遺伝子治療の基礎技術：58-67、羊土社 1996

 

13)    篠浦伸禎、濱田洋文　　個体をめざした動物細胞への遺伝子導入法・ウイルスベクター・レトロウイルス　　編集　斎藤泉、菅野純夫　　別冊実験医学　遺伝子導入＆発現解析実験法：58-62、羊土社 1997

 

14)    山口聰、濱田洋文　　がんの遺伝子治療・ 遺伝子治療のベクター：レトロウイルスベクター　がんと遺伝子・蛋白質 核酸 酵素42(10)：335(1789)-343(1797)、共立出版1997

 

15)    柴垣直孝、濱田洋文　　腫瘍免疫・サイトカイン導入腫瘍ワクチン　編集　菊地浩吉、矢田純一、奥村康　　Annual Review　免疫：355-361、中外医学社1997

 

16)    濱田洋文　　転移再発癌に対する遺伝子治療　　Surgery Frontier 4(3)：57(249)-62(254)、メディカルレビュー社1997

 

17)    柴垣直孝、濱田洋文　　癌遺伝子治療研究の課題と将来・遺伝子導入腫瘍ワクチン療法の課題　　血液・免疫・腫瘍　BIC Forum 2(3)：65(285)-70(290)、メディカルレビュー社1997

 

18)    濱田洋文　　特異的標的化を目指した癌の遺伝子治療法のストラテジー　Drug Delivery System  (Review article) 13: 143-149, 1998

 

19)    濱田洋文　　腫瘍細胞の特異的標的化を目指した遺伝子治療法の開発　　Oncology & Chemotherapy 13 (4):  265-271, 1997

 

20)    濱田洋文　　進行癌に対する遺伝子治療の方法論　　最新医学　53 (8): 82(1872)-88(1878), 1998

 

21)    濱田洋文　　遺伝子導入癌細胞を用いた免疫療法　特集　癌ワクチン療法　　Molecular Medicine 35 (9): 1138-1147, 1998

 

22)    濱田洋文　　サイトカイン遺伝子を用いた免疫遺伝子治療　　特集　悪性腫瘍に対する免疫学的細胞治療・遺伝子治療の新展開　　血液・腫瘍科（科学評論社）38(1):  15-21, 1999

 

23)     市川智継、田宮隆、足立、小野、松本、古田、大本、吉田陽子、濱田洋文　　Adenovirus vector による実験的脳腫瘍への遺伝子導入の検討、脳神経　50(8):731-8, 1998

 

24)     濱田洋文　　変異型アデノウイルスを用いた癌に対する遺伝子治療　　BIOTHERAPY 　TODAY（医薬ジャーナル社） 6 (1): 30-38, 1999

 

25)     濱田洋文　　大腸癌に対する遺伝子治療のストラテジー　　　医学のあゆみ 189(3)：194-195　(1999.4.17 発行)、1999

 

26)     濱田洋文  制限増殖型アデノウイルスによる癌の遺伝子治療　特集　細胞周期と癌治療　　Molecular Medicine 36 (10): 1256-1262, 1999

 

27)     濱田洋文　　　遺伝子治療ベクター開発：ウィルスベクターについて 　特集　遺伝子治療の基礎と臨床　　　組織細胞工学　１９９９年１０月号　ニューサイエンス社　　 25 (11): 4(426)-8(430), 1999

 

28)     内田宏昭、濱田洋文　　キャプシド変異型アデノウイルスを用いた癌の遺伝子治療　Biotherapy 14 (6): 615-621, June, 2000.

 

29)     内田宏昭、濱田洋文　　制限増殖型アデノウイルスを用いた癌の遺伝子治療　Biotherapy 14 (8) : 781-788, August, 2000.

 

30)     内田宏昭、濱田　洋文。　　サイトカイン・ケモカインを用いた癌の免疫遺伝子治療　医学のあゆみ　Vol.195 No.1 2000.10.7.

 

31)     濱田洋文　　遺伝子治療はどこまで進んでいるのか　分子がん治療　2: 81-82, 2001.

 

32)     濱田洋文　　次世代ウイルスベクターの作成と遺伝子治療への応用　細胞工学（秀潤社）　20(9): 1216-1221, 2001.

 

33)     濱田洋文　　がんに対する遺伝子治療のベクター開発　産科と婦人科（診断と治療社）68(9):1103-1109, 2001.

 

34)     濱田洋文　特集　細胞治療−再生医療への展開-アプローチ　再生医療の現状と展望　最新医学 56(12)　:7-13(2645-2651), 2001

 

35)     出張裕也、濱田洋文　　特集　遺伝子治療の新しい展開　６　アデノウイルスベクターの改変?改変型アデノウイルスによる癌遺伝子治療　　血液・免疫・腫瘍　7(2)：49(157)-54(162)、メディカルレビュー社 2002.

 

36)     Hamada H. [Gene therapy and regenerative medicine] Hokkaido Igaku Zasshi. 2002 Mar：　77(2)　:147-8.

 

37)     濱田洋文　　再生医療と遺伝子治療　　21世紀の癌医療と先端研究セミナーシリーズ　　佐藤昇志　編著　　東札幌病院教育研修委員会：　14-19、2002.

 

38)     増田ゆかり、濱田洋文　　標的化を目指したアデノウイルスベクターの開発　医学のあゆみ　203 (5)：384-389、2002.

 

39)     濱田洋文　　腫瘍の特異的標的化を目指した遺伝子治療：　ras依存的な殺腫瘍ウイルスベクター　「ウイルス」誌第53巻第2号（2003年12月号）　：195-199, 2003.

 

40)   　内田宏昭、濱田洋文　　アデノウィルスを用いたがん治療-腫瘍特異性の追求　「現代医療」　35（12）：　137-141、2003.

 

41)    濱田洋文 田中和美　佐々木勝則　　細胞標的化を目指した改変アデノウィルスベクター　ゲノム医学　3（6）：91-99、2003.

 

42)    伊藤克礼、濱田洋文　　心血管再生治療　リハビリテーション医学41巻第1号（2004年1月号）：　41-47，2004.

 

43)    濱田洋文　　癌治療の戦略　最新医学　59巻第8号(2004年8月号)：　44-51（1734-1741），2004.

 

44)    内田宏明、田原秀晃、濱田洋文　　siRNA発現アデノウィルスベクターの開発−悪性腫瘍に対する新しい遺伝子治療を目指してー　最新医学　59巻第8号(2004年8月号)　52-59（1742-1749），2004.

 

45)    濱田洋文　　遺伝子治療用ウイルスベクターの開発　実験医学　２２巻１４号（増刊）139-146（2037-2044），2004.

 

46)    濱田洋文　　制御増殖アデノウィルスによる遺伝子治療　特集　遺伝子治療　細胞　36（14）　18-21（582-585），2004.

 

47)    濱田洋文　　新しい分子生物学の手法：殺腫瘍ウィルス（oncolytic verus）　分子細胞治療　3(6)：　49-53, 2004.

 

48)    安倍井誠人、福田邦明、瀬尾恵美子、松崎靖司、田中直見、濱田洋文、横山和尚　　腫瘍選択的増殖型アデノウィルスを用いた胆道癌の遺伝子治療の研究と展望　特集　消化器疾患における最近の話題（ＩＩＩ）-胆道・膵臓　医学と薬学　52（6）　885-893，自然科学社　2004.

 

49)    濱田洋文　　特集　先端バイオテクノロジー先進医療開発を目指した挑戦的研究　腫瘍特異的な標的化ベクターの開発　　Surgery Frontier　12(1)：18-25、メディカルレビュー社 2005

 

50)    森川雅之、濱田洋文　　特集　下肢慢性閉塞性動脈硬化症に対する血管新生療法の新展開　1.　遺伝子治療VEGFおよびアンジオポエチン1を用いた血管新生遺伝子治療　　Angiology Frontier　5(1)：18-25、メディカルレビュー社 2006.

 

51)    加藤和則、濱田洋文　　標的細胞への選択的遺伝子導入法の開発　特集　臨床応用が迫る遺伝子治療の動向と国産技術の開発　　Drug Delivery System　22-6, 2007

 

「近況と話題」目次

2008年11月25日　標的化プロジェクト：現在までの成果と今後の課題

2008年11月11日　ものを送ってもらいたいとき

2008年11月7日　腫瘍の特異的標的化を目指した遺伝子治療法の開発

2008年6月27日　産学地域連携の課題

2006年3月20日　卒業式によせて：津山市立林田小学校の開校百年史から

2006年1月27日　グラフの形が違う！：　ユーア、ロングの思い出

2006年１月２７日　古代へのあこがれ：　「ズッコケ中年三人組」を読んでの読書感想文

2006年１月２７日　モダーンタイムズの医学研究における激甚捏造災害の被害者救済措置

2006年１月２７日　捏造、偽装、換骨奪胎。（第二部）

2006年１月25日　捏造、偽装、換骨奪胎。（第一部）

2006年１月２０日　冬はスキー！

2005年10月14日　子ぎつねへレンがのこしたもの

2005年9月5日　日暮れて道遠：　伍子胥と范蠡

2004年9月2日　エサトリに追われつつ、少年の成長の物語で予習

2005年8月31日　少年の成長の物語：　四万十川　あつよしの夏

2005年8月12日　夜と霧のパラドックス

2005年8月　3日塞翁が馬を適用して樹立された「抗体医薬を実用化するための副作用予測実験システム」（特許出願計画考慮中）

2005年　8月　3日　私の部屋に「猫町」を誘致

2005年　6月24日　怪力乱神を語ろう：　肺癌プロジェクト開始

2005年　6月　3日　石津謙介さんとフライデーカジュアル
2005年　6月　3日　33年前の疑問が解決

2005年　5月30日　ほんとうに言いたいことは何か？

2005年　5月13日　濱田先生が臥薪嘗胆を忘れる

2005年　4月11日　10年目の節目を迎えた、私の標的化遺伝子治療

2005年　3月23日　南氷洋の「洋」　　　

2005年　3月18日　短くまとめる、その3

2005年　3月18日　産学連携フォーラム　抄録

　「近況と話題」目次

  近況と話題　03/12/18 - 03/04/21　近況と話題　04/02/18 - 04/12/13

  近況と話題　01/07/31 - 01/05/01 　　近況と話題　01/04/27 - 01/01/22

遺伝子治療

再生医療